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1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) Proteins (AGPAT2)

AGPAT2 encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. Additionally we are shipping AGPAT2 Antibodies (37) and AGPAT2 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AGPAT2 10555 O15120
Rat AGPAT2 AGPAT2 311821  
AGPAT2 67512 Q8K3K7
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Top AGPAT2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

AGPAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) Interaction Partners

Human 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain.

  2. the ability of LPAAT-beta to regulate mTOR (show FRAP1 Proteins) function

  3. miR (show MLXIP Proteins)-24 may play an important role in inhibiting osteosarcoma growth through suppression of LPAATbeta.

  4. Data suggest that AGPAT2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K (show PIK3CA Proteins))/protooncogene c-Akt (show AKT1 Proteins) and PPARgamma (show PPARG Proteins) signaling in early stage of adipogenesis.

  5. the role of AGPAT1 (show AGPAT1 Proteins) or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin (show INS Proteins) resistance

  6. lpaat beta gene overexpression exists in both AML (show RUNX1 Proteins) and CML (show BCR Proteins) patients. lpaat beta produced by AML (show RUNX1 Proteins) cells probably plays an important role in abnormal proliferation and drug-resistance of AML (show RUNX1 Proteins) cells.

  7. Lysophosphatidic acid acyltransferase beta (LPAATbeta) promotes the tumor growth of human osteosarcoma

  8. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.

  9. Congenital lipodystrophy patients with Seipin (show BSCL2 Proteins) mutations have a more severe lack of body fat, which affects both metabolically active and mechanical adipose tissue, compared with patients with mutations in the AGPAT2 gene.

  10. mutations in AGPAT2 and Gng3lg (show BSCL2 Proteins) are approximately equally represented in congenital generalized lipodystrophy

Cow (Bovine) 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. Data indicate that the longissimus dorsi muscle (LM) of steers showed higher G0/G1 switch gene 2 (G0S2 (show G0S2 Proteins)) and comparative gene identification-58 (CGI-58 (show ABHD5 Proteins)) mRNA expression levels than the LM of bulls.

Mouse (Murine) 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. Adipogenically induced Agpat2(-/-) preadipocytes had fewer lipid-loaded cells and lower levels of adipocyte markers than wild type preadipocytes.

  2. Leptin (show LEP Proteins) ameliorates insulin (show INS Proteins) resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin (show LEP Proteins) receptors

  3. The lack of normal insulin (show INS Proteins) signaling in Agpat2(-/-) livers allows unrestricted phosphatidic acid-induced gluconeogenesis.

  4. Data suggest that Agpat2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt (show AKT1 Proteins) and PPARgamma (show PPARG Proteins) signaling in early stage of adipogenesis.

  5. the role of AGPAT1 (show AGPAT1 Proteins) or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin (show INS Proteins) resistance

  6. Loss of adipocytes by necrosis and apoptosis in Agpat2 null mice

  7. impaired AGPAT2 activity affects availability of phosphatidic acid (PA) for triacylglycerol synthesis but not overall PA synthesis nor utilization of PA for phospholipid synthesis

  8. The alternative monoacylglycerol pathway for triglyceride biosynthesis is activated in the absence of 1-acylglycerol-3-phosphate O-acyltransferase 2.

AGPAT2 Protein Profile

Protein Summary

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with AGPAT2

  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (AGPAT2)
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (agpat2)
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (agpat2)
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2)
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (Agpat2)
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2)
  • 1-AGPAT2 protein
  • 2510002J07Rik protein
  • AGPAT2 protein
  • AV000834 protein
  • BSCL protein
  • BSCL1 protein
  • LPAAB protein
  • LPAAT-beta protein
  • zgc:153984 protein

Protein level used designations for AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) , 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha , 1-AGP acyltransferase 2 , 1-AGPAT 2 , 1-acyl-sn-glycerol-3-phosphate acyltransferase beta , lysophosphatidic acid acyltransferase beta , lysophosphatidic acid acyltransferase-beta , lysophosphatidic acid acyltransferase, beta

GENE ID SPECIES
709753 Macaca mulatta
748669 Pan troglodytes
772114 Gallus gallus
777624 Danio rerio
100170486 Xenopus (Silurana) tropicalis
10555 Homo sapiens
311821 Rattus norvegicus
491249 Canis lupus familiaris
100170768 Sus scrofa
512112 Bos taurus
67512 Mus musculus
101114511 Ovis aries
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