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anti-2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) Antibodies

OAS1 encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. Additionally we are shipping OAS1 Kits (11) and OAS1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OAS1 192281 Q05961
OAS1 23961 Q60856
OAS1 4938 P00973
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Top anti-OAS1 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry with Small intestine tissue at an antibody concentration of 5µg/ml using anti-OAS1 antibody (ARP40401_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Transfected 293T Immunohistochemistry with Small intestine tissue at an antibody concentration of 5µg/ml using anti-OAS1 antibody (ARP51359_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart Immunohistochemistry with Tonsil tissue at an antibody concentration of 5µg/ml using anti-OAS1 antibody (ARP51360_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-OAS1 Pab (ABIN390164) is used in Western blot to detect OAS1 in mouse liver lysate. Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry with Small intestine tissue at an antibody concentration of 5µg/ml using anti-OAS1 antibody (ARP30587_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-OAS1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958394 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-OAS1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958314 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IF, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$566.50
Details

OAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Mouse (Murine)


Human , , , ,
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Top referenced anti-OAS1 Antibodies

  1. Human Polyclonal OAS1 Primary Antibody for IHC (p), WB - ABIN390164 : Gielen, Johnston, Edwards: Azithromycin induces anti-viral responses in bronchial epithelial cells. in The European respiratory journal 2010 (PubMed)
    Show all 12 references for ABIN390164

  2. Chicken Polyclonal OAS1 Primary Antibody for IHC, WB - ABIN2773987 : Phosri, Martín, Sihanonth, Whalley, Watling: Molecular study of the genus Astraeus. in Mycological research 2007 (PubMed)
    Show all 3 references for ABIN2773987

  3. Human Polyclonal OAS1 Primary Antibody for EIA, WB - ABIN358716 : Han, Townsend, Jha, Paranjape, Silverman, Barton: A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. in Journal of virology 2007 (PubMed)
    Show all 2 references for ABIN358716

  4. Human Polyclonal OAS1 Primary Antibody for IHC, WB - ABIN2778801 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 references for ABIN2778801

  5. Human Polyclonal OAS1 Primary Antibody for IHC, WB - ABIN2779349 : Li, Tainsky: Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway. in Cancer research 2011 (PubMed)

More Antibodies against OAS1 Interaction Partners

Cow (Bovine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Data indicate that the expression profiles of ISG15 (show ISG15 Antibodies), MX1 (show MX1 Antibodies), MX2 (show MX2 Antibodies), and OAS1 could be a useful diagnostic biomarker of gestation.

Chimpanzee 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Studied diversity of OAS1 in hominoids (focus on chimpanzees) and found the OAS1 gene extremely polymorphic in Central African chimpanzee and exhibits levels of silent and replacement diversity much higher than neutral regions of the chimpanzee genome.

Horse (Equine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. This study describes methylation patterns of CpG islands around the equine OAS1 locus in which polymorphic variants are associated with susceptibility to WNV infections

  2. Mutations in equine OAS1 contribute to host susceptibility to West Nile encephalitis.

Mouse (Murine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.

  2. Activation of Oas1b gene expression by type I IFN requires only STAT2 (show STAT2 Antibodies), not STAT1 (show STAT1 Antibodies).

  3. Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (show RNASEL Antibodies) activation.

  4. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

Human 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. ELF-1 (show EFNA2 Antibodies) binds an important duplicated GGAA cis (show CISH Antibodies)-acting element at the OAS1 promoter and in cooperation with RB1 (show RB1 Antibodies) and SP1 (show PSG1 Antibodies) recruitment contributes to regulation in response to IFN stimulation.

  2. Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases.

  3. The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584).

  4. Preliminary study suggests that OAS (show SMOC1 Antibodies) gene cluster and CD209 (show CD209 Antibodies) gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.

  5. While both OAS1-p42 (show EPB42 Antibodies) and p46 (show POLDIP3 Antibodies) showed antiviral activity against Dengue irus 2, only OAS1-p42 (show EPB42 Antibodies) presented anti-Dengue irus 1 activity.

  6. No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB (show SPTB Antibodies)) and preterm premature rupture of membranes (PPROM (show SERPINH1 Antibodies)).

  7. along with TLR3 (show TLR3 Antibodies), functions as a virus recognition receptor on mast cells activating the latent form of RNase L (show RNASEL Antibodies), leading to viral RNA degradation

  8. our research shows that the OAS1 rs10774671 SNP is associated with CA16 susceptibility and is correlated with mild and severe HFMD.

  9. The IFNs inhibit viral infections in part through the 2',5'-oligoadenylate (2-5A) synthetase (OAS (show SMOC1 Antibodies))/RNase L (show RNASEL Antibodies) pathway.

  10. The findings represent discovery of a novel signature for OAS1 activation, the 3'-single-stranded pyrimidine (3'-ssPy) motif, with potential functional implications for OAS1 activity in its antiviral and other anti-proliferative roles.

Pig (Porcine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.

  2. The active sites of OAS (show SMOC1 Antibodies) and CCA (show FBN2 Antibodies) class I enzymes are highly conserved.

OAS1 Antigen Profile

Protein Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with OAS1

  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1) antibody
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1Y) antibody
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa (OAS1) antibody
  • 2',5'-oligoadenylate synthetase 1 (OAS1) antibody
  • 2'-5' oligoadenylate synthetase 1A (Oas1a) antibody
  • 2'-5' oligoadenylate synthetase 1B (Oas1b) antibody
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1Z) antibody
  • Flv antibody
  • IFI-4 antibody
  • L1 antibody
  • Mmu-L1 antibody
  • Oas1 antibody
  • Oas1g antibody
  • OIAS antibody
  • Oias-2 antibody
  • Oias2 antibody
  • OIASI antibody
  • Wnv antibody

Protein level used designations for OAS1

2',5'-oligoadenylate synthetase 1, 40/46kDa , 2'-5'-oligoadenylate synthase 1 , 2'-5'-oligoadenylate synthetase 1 , 2'-5' oligoadenylate synthetase 1 , 2',5'-oligoadenylate synthetase 1 , 2'-5'-oligoadenylate synthetase 1-like , 2'-5'-oligoadenylate synthetase 1, 40/46kDa , (2-5')oligo(A) synthase 1 , (2-5')oligo(A) synthase 1A , (2-5')oligo(A) synthetase 1 , 2'-5' oligoadenylate synthetase 1G , 2'-5'-oligoadenylate synthase 1A , 2-5A synthase 1 , 2-5A synthase 1A , 2-5A synthetase 1 , 25 oligoadenylate synthetase , (2-5')oligo(A) synthase 1B , (2-5')oligo(A) synthetase 1b , 2',5'-oligoadenylate synthetase-like 1 , 2'-5'-oligoadenylate synthase 1B , 2'-5'-oligoadenylate synthase-like protein 1 , 2'-5'-oligoadenylate synthetase-like protein 1 , 2-5A synthase 1B , 2-5A synthetase 1B , Flavivirus resistance , inactive 2'-5'-oligoadenylate synthase 1B , 2',5'-oligo A synthetase 1 , 2'-5' oligoadenylate synthetase 1 p48 isoform , 2'-5' oligoadenylate synthetase 1 p52 isoform , 2'-5'-oligoisoadenylate synthetase 1 , E18/E16 , p46/p42 OAS , 2-5-oligoadenylate synthetase 1 , 2'-5' oligoadenylate synthetase , p42 OAS , 2'-5' oligoadenylate synthetase 1z

GENE ID SPECIES
347699 Bos taurus
654488 Bos taurus
712265 Macaca mulatta
739129 Pan troglodytes
100034147 Equus caballus
100172992 Pongo abelii
100294650 Ovis aries
100385368 Callithrix jacchus
100587554 Nomascus leucogenys
192281 Rattus norvegicus
23961 Mus musculus
4938 Homo sapiens
608778 Canis lupus familiaris
397570 Sus scrofa
519922 Bos taurus
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