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2',5'-Oligoadenylate Synthetase 1, 40/46kDa Proteins (OAS1)

OAS1 encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. Additionally we are shipping OAS1 Antibodies (80) and OAS1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OAS1 OAS1 192281 Q05961
Mouse OAS1 OAS1 23961 Q60856
OAS1 4938 P00973
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Top OAS1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$583.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,329.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$777.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OAS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced OAS1 Proteins

  1. Human OAS1 Protein expressed in Escherichia coli (E. coli) - ABIN666789 : Rios, Perelygin, Long, Lear, Zharkikh, Brinton, Adelson: Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes. in BMC genomics 2007 (PubMed)
    Show all 2 references for ABIN666789

  2. Human OAS1 Protein expressed in Wheat germ - ABIN1313295 : Yin, Zhou, Dai: The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization. in Lung cancer (Amsterdam, Netherlands) 2012 (PubMed)

More Proteins for 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) Interaction Partners

Cow (Bovine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Data indicate that the expression profiles of ISG15 (show ISG15 Proteins), MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 could be a useful diagnostic biomarker of gestation.

Chimpanzee 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Studied diversity of OAS1 in hominoids (focus on chimpanzees) and found the OAS1 gene extremely polymorphic in Central African chimpanzee and exhibits levels of silent and replacement diversity much higher than neutral regions of the chimpanzee genome.

Horse (Equine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. This study describes methylation patterns of CpG islands around the equine OAS1 locus in which polymorphic variants are associated with susceptibility to WNV infections

  2. Mutations in equine OAS1 contribute to host susceptibility to West Nile encephalitis.

Mouse (Murine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.

  2. Activation of Oas1b gene expression by type I IFN requires only STAT2 (show STAT2 Proteins), not STAT1 (show STAT1 Proteins).

  3. Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (show RNASEL Proteins) activation.

  4. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

Human 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. ELF-1 (show EFNA2 Proteins) binds an important duplicated GGAA cis (show CISH Proteins)-acting element at the OAS1 promoter and in cooperation with RB1 (show RB1 Proteins) and SP1 (show PSG1 Proteins) recruitment contributes to regulation in response to IFN stimulation.

  2. Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases.

  3. The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584).

  4. Preliminary study suggests that OAS (show SMOC1 Proteins) gene cluster and CD209 (show CD209 Proteins) gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.

  5. While both OAS1-p42 (show EPB42 Proteins) and p46 (show POLDIP3 Proteins) showed antiviral activity against Dengue irus 2, only OAS1-p42 (show EPB42 Proteins) presented anti-Dengue irus 1 activity.

  6. No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM (show SERPINH1 Proteins)).

  7. along with TLR3 (show TLR3 Proteins), functions as a virus recognition receptor on mast cells activating the latent form of RNase L (show RNASEL Proteins), leading to viral RNA degradation

  8. our research shows that the OAS1 rs10774671 SNP is associated with CA16 susceptibility and is correlated with mild and severe HFMD.

  9. The IFNs inhibit viral infections in part through the 2',5'-oligoadenylate (2-5A) synthetase (OAS (show SMOC1 Proteins))/RNase L (show RNASEL Proteins) pathway.

  10. The findings represent discovery of a novel signature for OAS1 activation, the 3'-single-stranded pyrimidine (3'-ssPy) motif, with potential functional implications for OAS1 activity in its antiviral and other anti-proliferative roles.

Pig (Porcine) 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) interaction partners

  1. Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.

  2. The active sites of OAS (show SMOC1 Proteins) and CCA (show FBN2 Proteins) class I enzymes are highly conserved.

OAS1 Protein Profile

Protein Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with OAS1

  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1)
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1Y)
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa (OAS1)
  • 2',5'-oligoadenylate synthetase 1 (OAS1)
  • 2'-5' oligoadenylate synthetase 1A (Oas1a)
  • 2'-5' oligoadenylate synthetase 1B (Oas1b)
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1Z)
  • Flv protein
  • IFI-4 protein
  • L1 protein
  • Mmu-L1 protein
  • Oas1 protein
  • Oas1g protein
  • OIAS protein
  • Oias-2 protein
  • Oias2 protein
  • OIASI protein
  • Wnv protein

Protein level used designations for OAS1

2',5'-oligoadenylate synthetase 1, 40/46kDa , 2'-5'-oligoadenylate synthase 1 , 2'-5'-oligoadenylate synthetase 1 , 2'-5' oligoadenylate synthetase 1 , 2',5'-oligoadenylate synthetase 1 , 2'-5'-oligoadenylate synthetase 1-like , 2'-5'-oligoadenylate synthetase 1, 40/46kDa , (2-5')oligo(A) synthase 1 , (2-5')oligo(A) synthase 1A , (2-5')oligo(A) synthetase 1 , 2'-5' oligoadenylate synthetase 1G , 2'-5'-oligoadenylate synthase 1A , 2-5A synthase 1 , 2-5A synthase 1A , 2-5A synthetase 1 , 25 oligoadenylate synthetase , (2-5')oligo(A) synthase 1B , (2-5')oligo(A) synthetase 1b , 2',5'-oligoadenylate synthetase-like 1 , 2'-5'-oligoadenylate synthase 1B , 2'-5'-oligoadenylate synthase-like protein 1 , 2'-5'-oligoadenylate synthetase-like protein 1 , 2-5A synthase 1B , 2-5A synthetase 1B , Flavivirus resistance , inactive 2'-5'-oligoadenylate synthase 1B , 2',5'-oligo A synthetase 1 , 2'-5' oligoadenylate synthetase 1 p48 isoform , 2'-5' oligoadenylate synthetase 1 p52 isoform , 2'-5'-oligoisoadenylate synthetase 1 , E18/E16 , p46/p42 OAS , 2-5-oligoadenylate synthetase 1 , 2'-5' oligoadenylate synthetase , p42 OAS , 2'-5' oligoadenylate synthetase 1z

GENE ID SPECIES
347699 Bos taurus
654488 Bos taurus
712265 Macaca mulatta
739129 Pan troglodytes
100034147 Equus caballus
100172992 Pongo abelii
100294650 Ovis aries
100385368 Callithrix jacchus
100587554 Nomascus leucogenys
192281 Rattus norvegicus
23961 Mus musculus
4938 Homo sapiens
608778 Canis lupus familiaris
397570 Sus scrofa
519922 Bos taurus
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