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2'-5' Oligoadenylate Synthetase 1B (OAS1B) ELISA Kits

OAS1B is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. Additionally we are shipping and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse OAS1B OAS1B 23961 Q60856
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More ELISA Kits for OAS1B Interaction Partners

Mouse (Murine) 2'-5' Oligoadenylate Synthetase 1B (OAS1B) interaction partners

  1. Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.

  2. Activation of Oas1b gene expression by type I IFN requires only STAT2 (show STAT2 ELISA Kits), not STAT1 (show STAT1 ELISA Kits).

  3. Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (show RNASEL ELISA Kits) activation.

  4. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

OAS1B Antigen Profile

Antigen Summary

This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product.

Gene names and symbols associated with OAS1B

  • 2'-5' oligoadenylate synthetase 1B (Oas1b) antibody
  • Flv antibody
  • L1 antibody
  • Mmu-L1 antibody
  • Oas1 antibody
  • Oias-2 antibody
  • Oias2 antibody
  • Wnv antibody

Protein level used designations for OAS1B

(2-5')oligo(A) synthase 1B , (2-5')oligo(A) synthetase 1b , 2',5'-oligoadenylate synthetase-like 1 , 2'-5'-oligoadenylate synthase 1B , 2'-5'-oligoadenylate synthase-like protein 1 , 2'-5'-oligoadenylate synthetase-like protein 1 , 2-5A synthase 1B , 2-5A synthetase 1B , Flavivirus resistance , inactive 2'-5'-oligoadenylate synthase 1B

GENE ID SPECIES
23961 Mus musculus
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