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3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Proteins (HMGCL)

The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Additionally we are shipping HMGCL Antibodies (105) and HMGCL Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMGCL 15356 P38060
HMGCL 3155 P35914
HMGCL 79238 P97519
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Top HMGCL Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$3,318.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

HMGCL Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced HMGCL Proteins

  1. Human HMGCL Protein expressed in Escherichia coli (E. coli) - ABIN667639 : Wang, Robert, Gibson, Wanders, Mitchell: 3-Hydroxy-3-methylglutaryl CoA lyase (HL): mouse and human HL gene (HMGCL) cloning and detection of large gene deletions in two unrelated HL-deficient patients. in Genomics 1996 (PubMed)
    Show all 2 references for ABIN667639

More Proteins for 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Interaction Partners

Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) interaction partners

  1. this is the first study describing HMGCL deficiency caused by uniparental disomy.

  2. This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR (show HMGCR Proteins) enzyme activity, tracing potential alterations in cholesterol biosynthesis.

  3. analysis of HMGCLL1 (show HMGCLL1 Proteins) as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL

  4. An alternative transcript of HMGCS2 (show HMGCS2 Proteins) carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  5. levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.

  6. Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.

  7. We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).

  8. A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG (show SSRP1 Proteins)-CoA cleavage reaction chemistry that leads to acetyl-CoA (show LPCAT2 Proteins) product formation.

  9. Data describe the DNA mutational analysis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.

  10. Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase

HMGCL Protein Profile

Protein Summary

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl)
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl)
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) (hmgcl)
  • Afu7g01720 protein
  • AO090038000541 protein
  • AW476067 protein
  • HL protein
  • zgc:56248 protein

Protein level used designations for HMGCL

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase , 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) , 3-hydroxy-3-methylglutarate-CoA lyase , HL , HMG-CoA lyase , hydroxymethylglutaryl-CoA lyase, mitochondrial , 3-hydroxy-3-methylglutaryl-CoA lyase , hydroxymethylglutaricaciduria , mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase , 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

GENE ID SPECIES
432233 Xenopus laevis
456624 Pan troglodytes
710833 Macaca mulatta
3504221 Aspergillus fumigatus Af293
4589480 Neosartorya fischeri NRRL 181
4704707 Aspergillus clavatus NRRL 1
5997540 Aspergillus oryzae RIB40
7030025 Talaromyces marneffei ATCC 18224
8102925 Talaromyces stipitatus ATCC 10500
9522067 Arthroderma benhamiae CBS 112371
9580122 Trichophyton verrucosum HKI 0517
100174514 Pongo abelii
15356 Mus musculus
3155 Homo sapiens
317658 Bos taurus
79238 Rattus norvegicus
396316 Gallus gallus
394190 Danio rerio
478187 Canis lupus familiaris
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