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3-Oxoacid CoA Transferase 1 Proteins (OXCT1)

OXCT1 encodes a member of the 3-oxoacid CoA-transferase gene family. Additionally we are shipping 3-Oxoacid CoA Transferase 1 Antibodies (45) and 3-Oxoacid CoA Transferase 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OXCT1 5019 P55809
OXCT1 67041 Q9D0K2
OXCT1 690163 B2GV06
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Top 3-Oxoacid CoA Transferase 1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,358.67
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,358.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OXCT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for 3-Oxoacid CoA Transferase 1 (OXCT1) Interaction Partners

Human 3-Oxoacid CoA Transferase 1 (OXCT1) interaction partners

  1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects.

  2. Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them.

  3. Data show that the ketone body metabolizing enzymes BDH1 (show BDH1 Proteins), BDH2 (show BDH2 Proteins), OXCT1 and ACAT1 (show ACAT1 Proteins) were expressed at the mRNA and protein level in all glioma cell lines.

  4. Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis.

  5. Results demonstrate that h-Scot-t (show OXCT2 Proteins) is a single intronless gene specifically expressed in the testis.

  6. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent.

  7. A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1.

  8. liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence

  9. The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes.

Pig (Porcine) 3-Oxoacid CoA Transferase 1 (OXCT1) interaction partners

  1. mechanism of SCOT catalysis

  2. Structure of the CoA transferase from pig heart to 1.7 A resolution

  3. On the basis of these results the conformational change in SCOT was deduced to be a domain rotation of 17 degrees coupled with movement of two loops: res. 321-329 that interact with succinate or acetoacetate and res. 374-386 that interact with CoA.

Mouse (Murine) 3-Oxoacid CoA Transferase 1 (OXCT1) interaction partners

  1. These results suggest that MT prevention of diabetes-induced pathological changes in cardiac tissues is most likely mediated by suppression of SCOT nitration at Trp (show TYRP1 Proteins)(374).

  2. Data suggest that to sustain survival and euglycemia during moderate-duration starvation, ketone body oxidation via Oxct1 is not required for energy transfer in three cell types: neurons, skeletal myocytes, and cardiomyocytes.

  3. Although Oxct1(-/-) mice exhibit normal prenatal development, all develop ketoacidosis, hypoglycemia, and reduced plasma lactate concentrations within the first 48 h of birth

3-Oxoacid CoA Transferase 1 (OXCT1) Protein Profile

Protein Summary

This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.

Gene names and symbols associated with OXCT1

  • 3-oxoacid CoA transferase 1a (oxct1a)
  • 3-oxoacid CoA transferase 1 (OXCT1)
  • 3-oxoacid CoA transferase 1 (oxct1)
  • 3-oxoacid CoA transferase 1 (MONBRDRAFT_35053)
  • 3-oxoacid CoA transferase 1 (Oxct1)
  • 2610008O03Rik protein
  • Oxct protein
  • OXCT1 protein
  • Oxct2a protein
  • SCOT protein
  • Scot-s protein
  • wu:fj36f06 protein
  • wu:fj48g08 protein
  • zgc:92003 protein

Protein level used designations for OXCT1

3-oxoacid CoA transferase 1 , SAGm18B , sagm18c , scot , succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial , succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like , 3-oxoacid CoA-transferase 1 , 3-oxoacid-CoA transferase 1 , SCOT-s , somatic-type succinyl CoA:3-oxoacid CoA-transferase , somatic-type succinyl-CoA:3-oxoacid CoA-transferase , somatic-type succinyl-CoA:3-oxoacid-CoA-transferase , succinyl CoA:3-oxoacid CoA transferase , succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial , succinyl-CoA:3-ketoacid-CoA transferase , succinyl-CoA:alpha-ketoacid coenzyme A transferase , succinyl-CoA:3-ketoacid CoA transferase , scot-S

GENE ID SPECIES
442923 Danio rerio
479347 Canis lupus familiaris
493307 Xenopus (Silurana) tropicalis
696642 Macaca mulatta
716730 Macaca mulatta
737468 Pan troglodytes
5889935 Monosiga brevicollis MX1
100151771 Felis catus
100173667 Pongo abelii
100414476 Callithrix jacchus
398820 Xenopus laevis
427190 Gallus gallus
5019 Homo sapiens
396978 Sus scrofa
535804 Bos taurus
67041 Mus musculus
690163 Rattus norvegicus
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