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4-Aminobutyrate Aminotransferase (ABAT) ELISA Kits

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Additionally we are shipping ABAT Antibodies (72) and ABAT Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ABAT ABAT 18 P80404
Anti-Mouse ABAT ABAT 268860 P61922
Anti-Rat ABAT ABAT 81632 P50554
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More ELISA Kits for ABAT Interaction Partners

Human 4-Aminobutyrate Aminotransferase (ABAT) interaction partners

  1. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 (show STC2 ELISA Kits) as predictive biomarkers for endocrine therapy resistance.

  2. A-to-G transition at nucleotide 754 of the human ABAT gene identified in lymphoblast cDNA (c.754A>G) results in substitution of an invariant arginine at amino acid 220 by lysine (p.Arg220Lys). This point mutation results in destabilization of the binding of pyridoxal-5'-phosphate to GABA-transaminase (required for transamination of GABA to succinic semialdehyde) and thus results in GABA-transaminase deficiency.

  3. Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders.

  4. direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES (show FUT3 ELISA Kits)) control in gastro esophageal reflux disease

  5. excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report]

  6. Marked differences in platelet uptake of GABA and activity of catabolic enzyme GABA-T between patients with generalized and localization-related epileptic syndromes. May indicate an impairment in function of brain GABAergic systems.

  7. results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT

  8. lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP (show PLP1 ELISA Kits) at the active site

  9. Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A (show GRIN2A ELISA Kits) and ABAT.

ABAT Antigen Profile

Antigen Summary

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Gene names and symbols associated with ABAT

  • 4-aminobutyrate aminotransferase (ABAT) antibody
  • 4-aminobutyrate aminotransferase (abat) antibody
  • 4-aminobutyrate aminotransferase (gabT) antibody
  • 4-aminobutyrate aminotransferase (gabT-1) antibody
  • 4-aminobutyrate aminotransferase (gabT-2) antibody
  • 4-aminobutyrate aminotransferase (gabT-3) antibody
  • 4-aminobutyrate aminotransferase (CNE01830) antibody
  • 4-aminobutyrate aminotransferase (Mmwyl1_0047) antibody
  • 4-aminobutyrate aminotransferase, mitochondrial (CpipJ_CPIJ008729) antibody
  • 4-aminobutyrate aminotransferase (Kcr_0880) antibody
  • 4-aminobutyrate aminotransferase (Bcenmc03_4909) antibody
  • 4-aminobutyrate aminotransferase (Hden_0972) antibody
  • 4-aminobutyrate aminotransferase (Dbac_2000) antibody
  • 4-aminobutyrate aminotransferase (Mesil_2400) antibody
  • 4-aminobutyrate aminotransferase (Trad_0121) antibody
  • 4-aminobutyrate aminotransferase (Abat) antibody
  • 9630038C02Rik antibody
  • AI255750 antibody
  • BA0325 antibody
  • beta-AlaAT antibody
  • cb880 antibody
  • ENSMUSG00000051226 antibody
  • fj82a01 antibody
  • GABA-AT antibody
  • GABA-T antibody
  • Gabaat antibody
  • Gabat antibody
  • Gm9851 antibody
  • I54 antibody
  • L-AIBAT antibody
  • Laibat antibody
  • NPD009 antibody
  • PSPTO0259 antibody
  • PSPTO0301 antibody
  • PSPTO1890 antibody
  • wu:fj82a01 antibody
  • X61497 antibody

Protein level used designations for ABAT

4-aminobutyrate aminotransferase, mitochondrial , GABA-T , 4-aminobutyrate aminotransferase , (S)-3-amino-2-methylpropionate transaminase , 4-aminobutyrate transaminase , GABA aminotransferase , GABA transaminase , GABA transferase , gamma-amino-N-butyrate transaminase , GABA-AT , L-AIBAT , beta-alanine oxoglutarate aminotransferase

GENE ID SPECIES
100051470 Equus caballus
378968 Danio rerio
416642 Gallus gallus
453903 Pan troglodytes
1086502 Bacillus anthracis str. Ames
1169096 Shewanella oneidensis MR-1
1181867 Pseudomonas syringae pv. tomato str. DC3000
1181910 Pseudomonas syringae pv. tomato str. DC3000
1183535 Pseudomonas syringae pv. tomato str. DC3000
3196857 Ruegeria pomeroyi DSS-3
3257776 Cryptococcus neoformans var. neoformans JEC21
5367528 Marinomonas sp. MWYL1
6041096 Culex quinquefasciatus
6094157 Candidatus Korarchaeum cryptofilum OPF8
6127721 Burkholderia cenocepacia MC0-3
9386856 Hyphomicrobium denitrificans ATCC 51888
100174312 Pongo abelii
1064855 Tropheryma whipplei TW08/27
8377675 Desulfomicrobium baculatum DSM 4028
9251916 Meiothermus silvanus DSM 9946
9279090 Truepera radiovictrix DSM 17093
398751 Xenopus laevis
18 Homo sapiens
397500 Sus scrofa
280969 Bos taurus
268860 Mus musculus
81632 Rattus norvegicus
479856 Canis lupus familiaris
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