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4-Aminobutyrate Aminotransferase Proteins (ABAT)

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Additionally we are shipping ABAT Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABAT 18 P80404
ABAT 268860 P61922
ABAT 81632 P50554
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Top ABAT Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,334.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ABAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for 4-Aminobutyrate Aminotransferase (ABAT) Interaction Partners

Human 4-Aminobutyrate Aminotransferase (ABAT) interaction partners

  1. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 (show STC2 Proteins) as predictive biomarkers for endocrine therapy resistance.

  2. A-to-G transition at nucleotide 754 of the human ABAT gene identified in lymphoblast cDNA (c.754A>G) results in substitution of an invariant arginine at amino acid 220 by lysine (p.Arg220Lys). This point mutation results in destabilization of the binding of pyridoxal-5'-phosphate to GABA-transaminase (required for transamination of GABA to succinic semialdehyde) and thus results in GABA-transaminase deficiency.

  3. Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders.

  4. direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES (show FUT3 Proteins)) control in gastro esophageal reflux disease

  5. excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report]

  6. Marked differences in platelet uptake of GABA and activity of catabolic enzyme GABA-T between patients with generalized and localization-related epileptic syndromes. May indicate an impairment in function of brain GABAergic systems.

  7. results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT

  8. lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP (show PLP1 Proteins) at the active site

  9. Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A (show GRIN2A Proteins) and ABAT.

ABAT Protein Profile

Protein Summary

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Gene names and symbols associated with ABAT

  • 4-aminobutyrate aminotransferase (ABAT)
  • 4-aminobutyrate aminotransferase (abat)
  • 4-aminobutyrate aminotransferase (gabT)
  • 4-aminobutyrate aminotransferase (gabT-1)
  • 4-aminobutyrate aminotransferase (gabT-2)
  • 4-aminobutyrate aminotransferase (gabT-3)
  • 4-aminobutyrate aminotransferase (CNE01830)
  • 4-aminobutyrate aminotransferase (Mmwyl1_0047)
  • 4-aminobutyrate aminotransferase, mitochondrial (CpipJ_CPIJ008729)
  • 4-aminobutyrate aminotransferase (Kcr_0880)
  • 4-aminobutyrate aminotransferase (Bcenmc03_4909)
  • 4-aminobutyrate aminotransferase (Hden_0972)
  • 4-aminobutyrate aminotransferase (Dbac_2000)
  • 4-aminobutyrate aminotransferase (Mesil_2400)
  • 4-aminobutyrate aminotransferase (Trad_0121)
  • 4-aminobutyrate aminotransferase (Abat)
  • 9630038C02Rik protein
  • AI255750 protein
  • BA0325 protein
  • beta-AlaAT protein
  • cb880 protein
  • ENSMUSG00000051226 protein
  • fj82a01 protein
  • GABA-AT protein
  • GABA-T protein
  • Gabaat protein
  • Gabat protein
  • Gm9851 protein
  • I54 protein
  • L-AIBAT protein
  • Laibat protein
  • NPD009 protein
  • PSPTO0259 protein
  • PSPTO0301 protein
  • PSPTO1890 protein
  • wu:fj82a01 protein
  • X61497 protein

Protein level used designations for ABAT

4-aminobutyrate aminotransferase, mitochondrial , GABA-T , 4-aminobutyrate aminotransferase , (S)-3-amino-2-methylpropionate transaminase , 4-aminobutyrate transaminase , GABA aminotransferase , GABA transaminase , GABA transferase , gamma-amino-N-butyrate transaminase , GABA-AT , L-AIBAT , beta-alanine oxoglutarate aminotransferase

GENE ID SPECIES
100051470 Equus caballus
378968 Danio rerio
416642 Gallus gallus
453903 Pan troglodytes
1086502 Bacillus anthracis str. Ames
1169096 Shewanella oneidensis MR-1
1181867 Pseudomonas syringae pv. tomato str. DC3000
1181910 Pseudomonas syringae pv. tomato str. DC3000
1183535 Pseudomonas syringae pv. tomato str. DC3000
3196857 Ruegeria pomeroyi DSS-3
3257776 Cryptococcus neoformans var. neoformans JEC21
5367528 Marinomonas sp. MWYL1
6041096 Culex quinquefasciatus
6094157 Candidatus Korarchaeum cryptofilum OPF8
6127721 Burkholderia cenocepacia MC0-3
9386856 Hyphomicrobium denitrificans ATCC 51888
100174312 Pongo abelii
1064855 Tropheryma whipplei TW08/27
8377675 Desulfomicrobium baculatum DSM 4028
9251916 Meiothermus silvanus DSM 9946
9279090 Truepera radiovictrix DSM 17093
398751 Xenopus laevis
18 Homo sapiens
397500 Sus scrofa
280969 Bos taurus
268860 Mus musculus
81632 Rattus norvegicus
479856 Canis lupus familiaris
Selected quality suppliers for ABAT Proteins (ABAT)
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