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5'-3' Exoribonuclease 2 Proteins (XRN2)

XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. Additionally we are shipping XRN2 Antibodies (34) and XRN2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
XRN2 22803 Q9H0D6
Mouse XRN2 XRN2 24128 Q9DBR1
Rat XRN2 XRN2 362229  
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Top XRN2 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

XRN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for 5'-3' Exoribonuclease 2 (XRN2) Interaction Partners

Human 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. Chromatin immunoprecipitation experiments further show that IL-1 (show IL1A Proteins) stimulation leads to decrease in NKRF (show NKRF Proteins) aa 421-429 phosphorylation and dissociation of NELF-E (show RDBP Proteins) and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter

  2. P-TEFb (show CCNT1 Proteins) regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.

  3. The results suggest that CARF (show CDKN2AIP Proteins) regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.

  4. Kinetic competition between elongating pol II and the Xrn2 exonuclease (show EXO1 Proteins) is integral to termination of transcription on most human genes.

  5. found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1 (show RNASEH1 Proteins)-mediated cleavage

  6. The restriction of JFH1 and H77D hepatitis C virus replication by Xrn2 is likely indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses.

  7. Xrn2 has a cytoplasmic, antiviral function against HCV that is counteracted by HCV's subversion of miR (show MLXIP Proteins)-122 to form a protective oligomeric complex at the 5' end of the viral genome.

  8. Mammalian target of rapamycin (show FRAP1 Proteins) protein regulates the diffusion of Xrn2 from the nucleolus to the nucleoplasm under heat stress conditions.

  9. hnRNPK (show HNRNPK Proteins) may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA processing (show PRPF39 Proteins) to transcription termination.

  10. Microprocessor orchestrates the recruitment of termination factors Setx (show SETX Proteins) and Xrn2, and the 3'-5' exoribonuclease, Rrp6 (show EXOSC10 Proteins), to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR (show RBM8A Proteins).

Mouse (Murine) 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. Genetic variants regulating Xrn2 expression in cis (show CISH Proteins) are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.

Arabidopsis thaliana 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. AtXRN2 has a role in ribosomal RNA processing.

  2. The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 (show SAL1 Proteins) are endogenous posttranscriptional gene silencing suppressors.

XRN2 Protein Profile

Protein Summary

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene\; however, their full-length nature is not known.

Gene names and symbols associated with 5'-3' Exoribonuclease 2 Proteins (XRN2)

  • 5'-3' exoribonuclease 2 (xrn2)
  • 5'-3' exoribonuclease 2 (XRN2)
  • 5'-3' exoribonuclease 2 (TA11675)
  • 5'-3' exoribonuclease 2 (LELG_04162)
  • 5'-3' exoribonuclease 2 (AOR_1_874194)
  • 5'-3' exoribonuclease 2 (PTRG_01514)
  • 5'-3' exoribonuclease 2 (PTRG_10866)
  • 5'-3' exoribonuclease 2 (Tsp_08094)
  • 5'-3' exoribonuclease 2 (LOC100353161)
  • 5'-3' exoribonuclease 2 (Xrn2)
  • AO090012000503 protein
  • AtXRN2 protein
  • DKFZp459J063 protein
  • exoribonuclease 2 protein
  • K16E1.2 protein
  • K16E1_2 protein
  • wu:fb38g12 protein
  • wu:fj53d06 protein
  • zgc:55717 protein

Protein level used designations for 5'-3' Exoribonuclease 2 Proteins (XRN2)

5'-3' exoribonuclease 2 , 5'-3' exoribonuclease 2-like , DHP protein , Dhm1-like protein (mouse homolog) , protein Dhm1

321940 Danio rerio
458131 Pan troglodytes
477133 Canis lupus familiaris
517417 Bos taurus
700934 Macaca mulatta
733834 Xenopus (Silurana) tropicalis
3861687 Theileria annulata strain Ankara
5231754 Lodderomyces elongisporus NRRL YB-4239
5987983 Aspergillus oryzae RIB40
6338441 Pyrenophora tritici-repentis Pt-1C-BFP
6349178 Pyrenophora tritici-repentis Pt-1C-BFP
10906655 Trichinella spiralis
100031372 Monodelphis domestica
100049102 Xenopus laevis
100050094 Equus caballus
100173960 Pongo abelii
100353161 Oryctolagus cuniculus
100388181 Callithrix jacchus
100468930 Ailuropoda melanoleuca
100517201 Sus scrofa
100593111 Nomascus leucogenys
22803 Homo sapiens
24128 Mus musculus
362229 Rattus norvegicus
421236 Gallus gallus
834261 Arabidopsis thaliana
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