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XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. Additionally we are shipping XRN2 Antibodies (38) and XRN2 Kits (3) and many more products for this protein.
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Human XRN2 Protein expressed in Human - ABIN2735705
Sedano, Sarnow: Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2. in Cell host & microbe 2014
Chromatin immunoprecipitation experiments further show that IL-1 (show IL1A Proteins) stimulation leads to decrease in NKRF (show NKRF Proteins) aa 421-429 phosphorylation and dissociation of NELF-E (show RDBP Proteins) and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter
P-TEFb (show CCNT1 Proteins) regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.
The results suggest that CARF (show CDKN2AIP Proteins) regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.
Kinetic competition between elongating pol II and the Xrn2 exonuclease (show EXO1 Proteins) is integral to termination of transcription on most human genes.
found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1 (show RNASEH1 Proteins)-mediated cleavage
The restriction of JFH1 and H77D hepatitis C virus replication by Xrn2 is likely indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses.
Xrn2 has a cytoplasmic, antiviral function against HCV that is counteracted by HCV's subversion of miR (show MLXIP Proteins)-122 to form a protective oligomeric complex at the 5' end of the viral genome.
Mammalian target of rapamycin (show FRAP1 Proteins) protein regulates the diffusion of Xrn2 from the nucleolus to the nucleoplasm under heat stress conditions.
hnRNPK (show HNRNPK Proteins) may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA processing (show PRPF39 Proteins) to transcription termination.
Microprocessor orchestrates the recruitment of termination factors Setx (show SETX Proteins) and Xrn2, and the 3'-5' exoribonuclease, Rrp6 (show EXOSC10 Proteins), to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR (show RBM8A Proteins).
Genetic variants regulating Xrn2 expression in cis (show CISH Proteins) are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.
AtXRN2 has a role in ribosomal RNA processing.
The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 (show SAL1 Proteins) are endogenous posttranscriptional gene silencing suppressors.
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene\; however, their full-length nature is not known.
5'-3' exoribonuclease 2
, 5'-3' exoribonuclease 2-like
, DHP protein
, Dhm1-like protein (mouse homolog)
, protein Dhm1