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XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. Additionally we are shipping XRN2 Kits (3) and XRN2 Proteins (3) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal XRN2 Primary Antibody for ICC, IF - ABIN252879
Barnhart, Moon, Emch, Wilusz, Wilusz: Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus. in Cell reports 2013
depletion of NKRF (show NKRF Antibodies), XRN2 or DHX15 (show DHX15 Antibodies) impairs an early pre-rRNA cleavage step.
XRN2 is a novel regulator of EMT (show ITK Antibodies) that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism.
XRN2 has a role in R-loop resolution, suppression of replication stress, and maintenance of genomic stability
Chromatin immunoprecipitation experiments further show that IL-1 (show IL1A Antibodies) stimulation leads to decrease in NKRF (show NKRF Antibodies) aa 421-429 phosphorylation and dissociation of NELF-E (show RDBP Antibodies) and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter
P-TEFb (show CCNT1 Antibodies) regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.
The results suggest that CARF (show CDKN2AIP Antibodies) regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.
Kinetic competition between elongating pol II and the Xrn2 exonuclease (show EXO1 Antibodies) is integral to termination of transcription on most human genes.
found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1 (show RNASEH1 Antibodies)-mediated cleavage
The restriction of JFH1 and H77D hepatitis C virus replication by Xrn2 is likely indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses.
Xrn2 has a cytoplasmic, antiviral function against HCV that is counteracted by HCV's subversion of miR (show MLXIP Antibodies)-122 to form a protective oligomeric complex at the 5' end of the viral genome.
Genetic variants regulating Xrn2 expression in cis (show CISH Antibodies) are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.
AtXRN2 has a role in ribosomal RNA processing.
The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 (show SAL1 PLURAL_@20275@) are endogenous posttranscriptional gene silencing suppressors.
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene\; however, their full-length nature is not known.
5'-3' exoribonuclease 2
, 5'-3' exoribonuclease 2-like
, DHP protein
, Dhm1-like protein (mouse homolog)
, protein Dhm1