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NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. Additionally we are shipping 5'-Nucleotidase, Cytosolic II Antibodies (56) and 5'-Nucleotidase, Cytosolic II Kits (2) and many more products for this protein.
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acute lymphoblastic leukemia-specific mutations affect regulation of cN-II
this study implicates altered neural expression of BORCS7, AS3MT (show AS3MT Proteins), and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.
The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.
Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.
cN-II co-immunoprecipitated both with wild type Ipaf (show NLRC4 Proteins) and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf (show NLRC4 Proteins) lacking the LRR domain.
Data indicate that type II cytosolic 5'-nucleotidase (show NT5E Proteins) (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.
Four novel body mass index-associated loci near the KCNQ1 (show KCNQ1 Proteins)(rs2237892), ALDH2 (show ALDH2 Proteins)/MYL2 (show MYL2 Proteins) (rs671, rs12229654), ITIH4 (show ITIH4 Proteins) (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.
These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia
results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia
The results on muscles from the NT5C (show NT5C Proteins) knockout mice contradict previous findings where AMP (show TMPRSS5 Proteins) levels and AMPK (show PRKAA1 Proteins) activity were shown to be modulated by NT5C (show NT5C Proteins) enzymes.
mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.
5'-nucleotidase, cytosolic II
, cytosolic 5'-nucleotidase II
, cytosolic purine 5'-nucleotidase
, cytosolic purine 5'-nucleotidase-like
, 5'-nucleotidase (purine), cytosolic type B
, IMP-specific 5'-NT
, purine 5' nucleotidase
, 5'-nucleotidase cytosolic II
, cytosolic IMP/GMP-specific 5'-nucleotidase