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NT5C3A encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. Additionally we are shipping 5'-Nucleotidase, Cytosolic IIIA Antibodies (14) and many more products for this protein.
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Human NT5C3A Protein expressed in Escherichia coli (E. coli) - ABIN2005962
Jordheim, Nguyen-Dumont, Thomas, Dumontet, Tavtigian: Differential allelic expression in leukoblast from patients with acute myeloid leukemia suggests genetic regulation of CDA, DCK, NT5C2, NT5C3, and TP53. in Drug metabolism and disposition: the biological fate of chemicals 2008
reduced expression of transketolase (show TKT Proteins) in pyrimidine 5'-nucleotidase (show NT5E Proteins) deficient patients
Pyrimidine-5'-nucleotidase (show NT5E Proteins) Campinas is a new mutation (p.R56G) in the NT5C3 (show NT5C3 Proteins) gene associated with pyrimidine-5'-nucleotidase (show NT5E Proteins) type I deficiency.
Results show that NT5C3 (show NT5C3 Proteins) expression levels were significantly increased in patients with risk allele homozygote.
New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase (show NT5E Proteins) type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia.
analysis of Drosophila and human 7-methyl GMP (show NT5C2 Proteins)-specific nucleotidases
Data show that PN-I (show NT5C Proteins) shows a higher affinity for oxynucleosides rather than deoxynucleosides, while the opposite is true for PN-II (show APP Proteins).
These data highlight hUMP1/POMP (show POMP Proteins) role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system.
In leukoblasts from 82 patients with acute myeloid leukemia (show BCL11A Proteins), various extent and frequency of differential allelic expression in the CDA (show CDA Proteins), DCK (show DCK Proteins), NT5C2 (show NT5C2 Proteins), NT5C3 (show NT5C3 Proteins), and TP53 (show TP53 Proteins) genes was observed.
genetic variation in NT5C3 (show NT5C3 Proteins) might affect protein function and potentially influence drug response
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4.
5'-nucleotidase, cytosolic III
, cytosolic 5'-nucleotidase 3
, cytosolic 5'-nucleotidase 3A
, pyrimidine 5'-nucleotidase 1
, uridine 5'-monophosphate hydrolase 1