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Contributes to tetrahydrofolate metabolism.
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Expression of the MTHFS cDNA in MCF-7 cells increased the concentration of NADA required to deplete cellular folate.
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids (By similarity).
, 5-formyltetrahydrofolate cyclo-ligase
, methenyl-THF synthetase
, 5, 10-methenyltetrahydrofolate synthetase