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5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) ELISA Kits

ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Antibodies (64) and ATIC Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ATIC ATIC 471 P31939
Anti-Mouse ATIC ATIC 108147 Q9CWJ9
Anti-Rat ATIC ATIC 81643 O35567
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Top ATIC ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Chicken
96 Tests Log in to see 16 to 21 Days
$999.43
Details

More ELISA Kits for ATIC Interaction Partners

Human 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) interaction partners

  1. ATIC 347C>G gene polymorphism may be associated with the development of MTX (show MTX1 ELISA Kits) induced gastrointestinal adverse events.

  2. genotyping of ATIC rs2372536 and ITPA (show ITPA ELISA Kits) rs1127354 variants or measuring ITPA (show ITPA ELISA Kits) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.

  3. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (show GGH ELISA Kits) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma

  4. Our data show that ATIC is in complex with insulin receptor (IR (show INSR ELISA Kits))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (show INS ELISA Kits) stimulation and ATIC knockdown readily increase level of AMPK (show PRKAA1 ELISA Kits)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (show INS ELISA Kits) response of Glut2 (show SLC2A2 ELISA Kits) translocation in HEK293 cells and decreased AKT (show AKT1 ELISA Kits)-Ser473 phosphorylation.

  5. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.

  6. MTHFR (show MTHFR ELISA Kits), DHFR (show DHFR ELISA Kits) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 ELISA Kits) monotherapy.

  7. study suggests that MTHFR (show MTHFR ELISA Kits) C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX (show MTX1 ELISA Kits) treatment and, therefore, assist clinicians in personalizing RA treatment

  8. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly.

  9. The kinetic mechanism of the human bifunctional enzyme ATIC

  10. crystal structure of ATIC

ATIC Antigen Profile

Antigen Summary

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Gene names and symbols associated with ATIC

  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (atic) antibody
  • bifunctional purine biosynthesis protein PurH (purH) antibody
  • bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein PurH (purH) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic) antibody
  • 2610509C24Rik antibody
  • AA536954 antibody
  • AICAR antibody
  • AICARFT antibody
  • AW212393 antibody
  • IMPCHASE antibody
  • purH antibody

Protein level used designations for ATIC

bifunctional purine biosynthesis protein PurH , bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein PurH , 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase , AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme , AICARFT/IMPCHASE , bifunctional purine biosynthesis protein PURH , phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase , 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC , aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase , aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase , bifunctional purine biosynthesis protein

GENE ID SPECIES
735175 Xenopus laevis
1064322 Tropheryma whipplei TW08/27
1795643 Rhodopirellula baltica SH 1
3726377 Carboxydothermus hydrogenoformans Z-2901
3852615 Salinibacter ruber DSM 13855
4056143 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)
4289939 Hyphomonas neptunium ATCC 15444
6413645 Cellvibrio japonicus Ueda107
6944185 Coprothermobacter proteolyticus DSM 5265
6945486 Dictyoglomus thermophilum H-6-12
7355505 Thermomicrobium roseum DSM 5159
8213748 Teredinibacter turnerae T7901
8220261 Neorickettsia risticii str. Illinois
8867387 Deferribacter desulfuricans SSM1
8984725 Bacillus megaterium QM B1551
8996427 Salinibacter ruber M8
9115672 Bacillus megaterium DSM 319
9399564 Leuconostoc gasicomitatum LMG 18811
9444476 Clostridium ljungdahlii DSM 13528
9486490 Candidatus Nitrospira defluvii
9728858 Streptococcus pneumoniae 670-6B
9773527 Paenibacillus polymyxa E681
9796745 Arthrobacter arilaitensis Re117
9902632 Rothia dentocariosa ATCC 17931
9904419 Gardnerella vaginalis ATCC 14019
10101946 Candidatus Blochmannia vafer str. BVAF
10974211 Zobellia galactanivorans
471 Homo sapiens
396091 Gallus gallus
488513 Canis lupus familiaris
100170854 Sus scrofa
506343 Bos taurus
108147 Mus musculus
81643 Rattus norvegicus
100346623 Oryctolagus cuniculus
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