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5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase Proteins (ATIC)

ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Antibodies (64) and ATIC Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATIC 471 P31939
ATIC 108147 Q9CWJ9
ATIC 81643 O35567
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Top ATIC Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macrococcus caseolyticus His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
Yeast REACT_Staphylococcus epidermis His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
Yeast Staphylococcus aureus His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
Yeast Clostridium His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,703.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ATIC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Interaction Partners

Human 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) interaction partners

  1. ATIC 347C>G gene polymorphism may be associated with the development of MTX (show MTX1 Proteins) induced gastrointestinal adverse events.

  2. genotyping of ATIC rs2372536 and ITPA (show ITPA Proteins) rs1127354 variants or measuring ITPA (show ITPA Proteins) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.

  3. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (show GGH Proteins) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma

  4. Our data show that ATIC is in complex with insulin receptor (IR (show INSR Proteins))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (show INS Proteins) stimulation and ATIC knockdown readily increase level of AMPK (show PRKAA1 Proteins)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (show INS Proteins) response of Glut2 (show SLC2A2 Proteins) translocation in HEK293 cells and decreased AKT (show AKT1 Proteins)-Ser473 phosphorylation.

  5. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.

  6. MTHFR (show MTHFR Proteins), DHFR (show DHFR Proteins) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 Proteins) monotherapy.

  7. study suggests that MTHFR (show MTHFR Proteins) C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX (show MTX1 Proteins) treatment and, therefore, assist clinicians in personalizing RA treatment

  8. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly.

  9. The kinetic mechanism of the human bifunctional enzyme ATIC

  10. crystal structure of ATIC

ATIC Protein Profile

Protein Summary

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Gene names and symbols associated with ATIC

  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (atic)
  • bifunctional purine biosynthesis protein PurH (purH)
  • bifunctional purine biosynthesis protein purH (purH)
  • Bifunctional purine biosynthesis protein purH (purH)
  • Bifunctional purine biosynthesis protein PurH (purH)
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC)
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic)
  • 2610509C24Rik protein
  • AA536954 protein
  • AICAR protein
  • AICARFT protein
  • AW212393 protein
  • IMPCHASE protein
  • purH protein

Protein level used designations for ATIC

bifunctional purine biosynthesis protein PurH , bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein PurH , 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase , AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme , AICARFT/IMPCHASE , bifunctional purine biosynthesis protein PURH , phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase , 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC , aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase , aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase , bifunctional purine biosynthesis protein

GENE ID SPECIES
735175 Xenopus laevis
1064322 Tropheryma whipplei TW08/27
1795643 Rhodopirellula baltica SH 1
3726377 Carboxydothermus hydrogenoformans Z-2901
3852615 Salinibacter ruber DSM 13855
4056143 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)
4289939 Hyphomonas neptunium ATCC 15444
6413645 Cellvibrio japonicus Ueda107
6944185 Coprothermobacter proteolyticus DSM 5265
6945486 Dictyoglomus thermophilum H-6-12
7355505 Thermomicrobium roseum DSM 5159
8213748 Teredinibacter turnerae T7901
8220261 Neorickettsia risticii str. Illinois
8867387 Deferribacter desulfuricans SSM1
8984725 Bacillus megaterium QM B1551
8996427 Salinibacter ruber M8
9115672 Bacillus megaterium DSM 319
9399564 Leuconostoc gasicomitatum LMG 18811
9444476 Clostridium ljungdahlii DSM 13528
9486490 Candidatus Nitrospira defluvii
9728858 Streptococcus pneumoniae 670-6B
9773527 Paenibacillus polymyxa E681
9796745 Arthrobacter arilaitensis Re117
9902632 Rothia dentocariosa ATCC 17931
9904419 Gardnerella vaginalis ATCC 14019
10101946 Candidatus Blochmannia vafer str. BVAF
10974211 Zobellia galactanivorans
471 Homo sapiens
396091 Gallus gallus
488513 Canis lupus familiaris
100170854 Sus scrofa
506343 Bos taurus
108147 Mus musculus
81643 Rattus norvegicus
100346623 Oryctolagus cuniculus
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