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This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.
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Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT (show DDC Antibodies) activation of 5-HT2B receptors in postnatal microglial cells
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter (show SLC6A4 Antibodies) has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR (show PPARA Antibodies)-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT (show DDC Antibodies)(2A)/5HT (show DDC Antibodies)(2B) receptors.
5-HT(2B) R [deficiency] interferes with the mechanisms directing amelogenesis
Activation of 5-HT(2B) receptors on bone marrow lineage progenitors is critical for the development of pulmonary arterial hypertension.
5-HT2B blockade enhances liver regeneration by inhibiting induction of TGF-beta1 (show TGFB1 Antibodies) expression by hepatic stellate cells that is dependent on 5-HT (show DDC Antibodies), ERK (show EPHB2 Antibodies) and JunD (show JUND Antibodies).
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
, 5-hydroxytryptamine receptor 2B
, NP75 protein
, serotonin receptor 2B
, 5-HT2B serotonin receptor