anti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Antibodies

ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Proteins (12) and ATIC Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATIC 471 P31939
ATIC 108147 Q9CWJ9
ATIC 81643 O35567
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Top anti-ATIC Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-ATIC Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>HepG2 cell lysate <b>Sample Type:</b> 1. Hamster CHO K1 cells (20ug)<br>2. HeLa skin cells(20ug)<br>3. HEK273 cells (20ug)<br>4. Human Skin Fibroblats (100ug)<br><b>Primary Dilution:</b> 1:800<br><b>Secondary Antibody:</b> Clean-Blot IP detection Reagent and Kit<br><b>Secondary Dilution:</b> 1:2000<br><b>Image Submitted By:</b> V. Skopova, M. Zikanova<br>Institute of Inherited Metabolic Disorders, Charles University in Prague and General Hopspital in Prague 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Fruit Fly Mouse Un-conjugated IHC (p), WB 0.1 mg Log in to see 3 to 4 Days
$271.76
Details
Cow Mouse Un-conjugated IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with ATIC antibody ABIN214223 at 15 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Fruit Fly Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATIC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATIC. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATIC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATIC. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATIC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATIC. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Dog Mouse Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$493.17
Details
Dog Mouse Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$493.17
Details

ATIC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-ATIC Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal ATIC Primary Antibody for IHC (p), WB - ABIN2477543 : Rattan, Giri, Singh, Singh: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against ATIC Interaction Partners

Human 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) interaction partners

  1. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy

  2. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.

  3. ATIC 347C>G gene polymorphism may be associated with the development of MTX (show MTX1 Antibodies) induced gastrointestinal adverse events.

  4. genotyping of ATIC rs2372536 and ITPA (show ITPA Antibodies) rs1127354 variants or measuring ITPA (show ITPA Antibodies) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.

  5. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (show GGH Antibodies) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma

  6. Our data show that ATIC is in complex with insulin receptor (IR (show INSR Antibodies))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (show INS Antibodies) stimulation and ATIC knockdown readily increase level of AMPK (show PRKAA1 Antibodies)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (show INS Antibodies) response of Glut2 (show SLC2A2 Antibodies) translocation in HEK293 cells and decreased AKT (show AKT1 Antibodies)-Ser473 phosphorylation.

  7. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.

  8. MTHFR (show MTHFR Antibodies), DHFR (show DHFR Antibodies) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 Antibodies) monotherapy.

  9. study suggests that MTHFR (show MTHFR Antibodies) C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX (show MTX1 Antibodies) treatment and, therefore, assist clinicians in personalizing RA treatment

  10. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly.

ATIC Antigen Profile

Protein Summary

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Gene names and symbols associated with ATIC

  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (atic) antibody
  • bifunctional purine biosynthesis protein PurH (purH) antibody
  • bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein purH (purH) antibody
  • Bifunctional purine biosynthesis protein PurH (purH) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) antibody
  • 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic) antibody
  • 2610509C24Rik antibody
  • AA536954 antibody
  • AICAR antibody
  • AICARFT antibody
  • AW212393 antibody
  • IMPCHASE antibody
  • purH antibody

Protein level used designations for ATIC

bifunctional purine biosynthesis protein PurH , bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein purH , Bifunctional purine biosynthesis protein PurH , 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase , AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme , AICARFT/IMPCHASE , bifunctional purine biosynthesis protein PURH , phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase , 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC , aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase , aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase , bifunctional purine biosynthesis protein

GENE ID SPECIES
735175 Xenopus laevis
1064322 Tropheryma whipplei TW08/27
1795643 Rhodopirellula baltica SH 1
3726377 Carboxydothermus hydrogenoformans Z-2901
3852615 Salinibacter ruber DSM 13855
4056143 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)
4289939 Hyphomonas neptunium ATCC 15444
6413645 Cellvibrio japonicus Ueda107
6944185 Coprothermobacter proteolyticus DSM 5265
6945486 Dictyoglomus thermophilum H-6-12
7355505 Thermomicrobium roseum DSM 5159
8213748 Teredinibacter turnerae T7901
8220261 Neorickettsia risticii str. Illinois
8867387 Deferribacter desulfuricans SSM1
8984725 Bacillus megaterium QM B1551
8996427 Salinibacter ruber M8
9115672 Bacillus megaterium DSM 319
9399564 Leuconostoc gasicomitatum LMG 18811
9444476 Clostridium ljungdahlii DSM 13528
9486490 Candidatus Nitrospira defluvii
9728858 Streptococcus pneumoniae 670-6B
9773527 Paenibacillus polymyxa E681
9796745 Arthrobacter arilaitensis Re117
9902632 Rothia dentocariosa ATCC 17931
9904419 Gardnerella vaginalis ATCC 14019
10101946 Candidatus Blochmannia vafer str. BVAF
10974211 Zobellia galactanivorans
471 Homo sapiens
396091 Gallus gallus
488513 Canis lupus familiaris
100170854 Sus scrofa
506343 Bos taurus
108147 Mus musculus
81643 Rattus norvegicus
100346623 Oryctolagus cuniculus
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