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ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. Additionally we are shipping ATIC Antibodies (74) and ATIC Kits (1) and many more products for this protein.
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Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy
The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.
ATIC 347C>G gene polymorphism may be associated with the development of MTX (show MTX1 Proteins) induced gastrointestinal adverse events.
genotyping of ATIC rs2372536 and ITPA (show ITPA Proteins) rs1127354 variants or measuring ITPA (show ITPA Proteins) activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis.
This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH (show GGH Proteins) genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma
Our data show that ATIC is in complex with insulin receptor (IR (show INSR Proteins))and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin (show INS Proteins) stimulation and ATIC knockdown readily increase level of AMPK (show PRKAA1 Proteins)-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin (show INS Proteins) response of Glut2 (show SLC2A2 Proteins) translocation in HEK293 cells and decreased AKT (show AKT1 Proteins)-Ser473 phosphorylation.
Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease.
MTHFR (show MTHFR Proteins), DHFR (show DHFR Proteins) and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 Proteins) monotherapy.
study suggests that MTHFR (show MTHFR Proteins) C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX (show MTX1 Proteins) treatment and, therefore, assist clinicians in personalizing RA treatment
Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly.
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
bifunctional purine biosynthesis protein PurH
, bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein purH
, Bifunctional purine biosynthesis protein PurH
, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase
, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
, bifunctional purine biosynthesis protein PURH
, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
, 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC
, aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase
, aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase
, bifunctional purine biosynthesis protein