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The protein encoded HTR3D belongs to the ligand-gated ion channel receptor superfamily.
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Data show that 5-HT3C, 5-HT3D, and 5-HT3E (show HTR3E Proteins) subunits are coexpressed with 5-HT3A (show HTR3A Proteins) in cell bodies of myenteric neurons, and that 5-HT3A (show HTR3A Proteins) and 5-HT3D were expressed in submucosal plexus of the human large intestine.
Polymorphism in HTR3D shows differential risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.
Six functional and coding variants of the subunit genes HTR3A (show HTR3A Proteins), HTR3B (show HTR3B Proteins) as well as the novel HTR3C, HTR3D, and HTR3E (show HTR3E Proteins) subunits in the response to haloperidol or risperidone, were assessed.
The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
5-hydroxytryptamine (serotonin) receptor 3 family member D
, 5-hydroxytryptamine receptor 3 subunit D
, 5-hydroxytryptamine receptor 3D
, serotonin 5-HT-3D receptor
, serotonin receptor 3D