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6-Pyruvoyltetrahydropterin Synthase Proteins (PTS)

The enzyme encoded by PTS catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Additionally we are shipping PTS Antibodies (51) and PTS Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTS 29498 P27213
PTS 19286 Q9R1Z7
PTS 5805 Q03393
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Top PTS Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$322.14
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,185.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,299.00
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,315.50
Details
Yeast REACT_Guppy His tag   1 mg Log in to see 56 to 66 Days
$2,321.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PTS Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , ,
,

Top referenced PTS Proteins

  1. Human PTS Protein expressed in Escherichia coli (E. coli) - ABIN2006152 : Ashida, Owada, Hatakeyama: A missense mutation (A to G) of 6-pyruvoyltetrahydropterin synthase in tetrahydrobiopterin-deficient form of hyperphenylalaninemia. in Genomics 1995 (PubMed)
    Show all 2 references for ABIN2006152

More Proteins for 6-Pyruvoyltetrahydropterin Synthase (PTS) Interaction Partners

Mouse (Murine) 6-Pyruvoyltetrahydropterin Synthase (PTS) interaction partners

  1. biopterin contents in the brains of these knock-out mice were moderately decreased from postnatal day 0 (P0) and remained constant up to P21

  2. ptps has a role in 6-pyruvoyltetrahydropterin synthase- or BH4-biosynthetic activity with IGF-1 (show IGF1 Proteins)

Human 6-Pyruvoyltetrahydropterin Synthase (PTS) interaction partners

  1. Severe neurological impairment from BH4 deficiency could be prevented by newborn screening for hyperphenylalaninemia (HPA (show HPSE Proteins)) and proper metabolic management.

  2. A total of 43 mutations were identified in the PTS gene in a screen of East Asian populations, comprising 22 previously reported mutations and 21 new discovered mutations.

  3. The mutant characterization of PTPS gene was coincident with other early studies in Chinese. The novel mutation L127F was considered as a pathogenetic mutation and associated with severe clinical phenotype.

  4. Our data show that PTPS induction is necessary for optimized BH4 synthesis in cytokine-stimulated human coronary artery endothelial cells and point to IL-1beta (show IL1B Proteins) as a leading cytokine in this process.

  5. Human PTS was efficiently expressed in noradrenergic regions but only in a small number of dopaminergic neurons.

  6. Expression of PTS was significantly decreased in PD cases.

  7. We suggest that the serum prolactin (show PRL Proteins) level may be a more sensitive marker than the CSF (show CSF2 Proteins) HVA level to guide the dose adjustment of L-Dopa/carbidopa in the management of patients with PTPS deficiency.

PTS Protein Profile

Protein Summary

The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.

Gene names and symbols associated with PTS

  • 6-pyruvoyltetrahydropterin synthase (PTS)
  • 6-pyruvoyltetrahydropterin synthase (pts)
  • 6-pyruvoyltetrahydropterin synthase (Pts)
  • 6-pyruvoyltetrahydropterin synthase (azo3118)
  • 6-pyruvoyltetrahydropterin synthase (Xfasm12_0164)
  • 6-pyruvoyltetrahydropterin synthase (Huta_2000)
  • 6-pyruvoyltetrahydropterin synthase (Cyan8802_3683)
  • 6-pyruvoyltetrahydropterin synthase (ptsA)
  • 6-pyruvoyltetrahydropterin synthase (Nmag_3513)
  • 6-pyruvoyltetrahydropterin synthase (DICPUDRAFT_151723)
  • 6-pyruvoyl-tetrahydropterin synthase (Pts)
  • DDBDRAFT_0232952 protein
  • DDB_0232952 protein
  • PTPS protein
  • Pts protein
  • zgc:162276 protein

Protein level used designations for PTS

6-pyruvoyltetrahydropterin synthase , 6-pyruvoyl tetrahydrobiopterin synthase , putative 6-pyruvoyltetrahydropterin synthase , PTP synthase , PTPS

GENE ID SPECIES
374144 Gallus gallus
495178 Xenopus laevis
506860 Bos taurus
611326 Canis lupus familiaris
692791 Bombyx mori
711642 Macaca mulatta
739126 Pan troglodytes
2734138 Bdellovibrio bacteriovorus HD100
4607798 Azoarcus sp. BH72
6121154 Xylella fastidiosa M12
8384294 Halorhabdus utahensis DSM 12940
8393025 Cyanothece sp. PCC 8802
8621869 Dictyostelium discoideum AX4
8826381 Natrialba magadii ATCC 43099
100073330 Danio rerio
100190535 Taeniopygia guttata
10500652 Dictyostelium purpureum
29498 Rattus norvegicus
19286 Mus musculus
5805 Homo sapiens
100171600 Pongo abelii
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