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anti-7-Dehydrocholesterol Reductase (DHCR7) Antibodies

DHCR7 encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. Additionally we are shipping DHCR7 Kits (10) and DHCR7 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DHCR7 13360 O88455
DHCR7 64191 Q9Z2Z8
DHCR7 1717 Q9UBM7
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Top anti-DHCR7 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated IF, IHC (p), WB DHCR7 Antibody (C-term) (ABIN655399) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit PE ICC, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IF, IHC (p), WB   400 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

DHCR7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DHCR7 Antibodies

  1. Mouse (Murine) Polyclonal DHCR7 Primary Antibody for IF, IHC (p) - ABIN655399 : Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010 (PubMed)

More Antibodies against DHCR7 Interaction Partners

Xenopus laevis 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog (show SHH Antibodies) are co-expressed during midline development in Xenopus embryos.

  2. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system

Arabidopsis thaliana 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles

Mouse (Murine) 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. significant increases in Col1a1 (show COL1A1 Antibodies), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 Antibodies), CSRNP1 (show CSRNP1 Antibodies), Ddit4 (show DDIT4 Antibodies), Cyp2e1 (show CYP2E1 Antibodies), and Krit1 (show KRIT1 Antibodies) expressions and great decreases inreceptor D2, Neu1 (show NEURL Antibodies), and Dhcr7 expressions following long-term exposure to TiO2 NPs (show NPS Antibodies)

  2. data indicate an underlying dysfunction of the 5-HT2A (show HTR2A Antibodies) receptors in Dhcr7-HET mice that warrants further investigation to establish how this may relate to behavioral disturbances in human patients carrying Dhcr7 mutations

  3. conclude that cytochrome P450 reductase (show POR Antibodies) is not involved in 7-dehydrocholesterol reductase activity

  4. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d (show SC5DL Antibodies)(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

  5. Immunohistochemical analyses have revealed a 306% increase in the area of 5-HT (show DDC Antibodies) immunoreactivity (5-HT (show DDC Antibodies) IR) in the hindbrains of mutant (Dhcr7-/-) mice as compared to age-matched wild type animals.

  6. Of the 12,000 genes analyzed, 91 were upregulated and 98 were downregulated in the Dhcr7-/- hindbrains when compared to wild-type animals.

  7. CNS defects caused by Dhcr7 null likely play a major role in the lethal pathogenesis of Dhcr7-/- mice, with the peripheral organs contributing the morbidity

  8. Data show that in vitro down regulation of NRIF (show ZFP110 Antibodies) expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (show HMGCR Antibodies) and 7-dehydrocholesterol reductase.

  9. down-regulation of Dhcr7 altered expression of multiple molecules that play critical roles in intracellular signaling or vesicular transport or are inserted into membrane rafts, and down-regulated several critical genes involved in lipid biosynthesis

  10. Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome

Human 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.

  2. The aim of this study was to investigate the association of three polymorphisms in the GC gene (rs7041 and rs4588) and CYP2R1 (show CYP2R1 Antibodies) gene (rs10741657) on 25-(OH) VD serum concentration among Jordanians.

  3. This study shows that Smith-Lemli-Opitz Syndrome patients who are heterozygous/homozygous for one pathogenic mutation and only one parent carrying that mutation are candidates for DHCR7 gene (partial) deletions.

  4. Polymorphisms in CYP2R1 (show CYP2R1 Antibodies)-rs10766197 and DHCR7/NADSYN1 (show NADSYN1 Antibodies)-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations

  5. physical and functional interaction between DHCR24 (show DHCR24 Antibodies) and DHCR7

  6. In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 (show CYP2R1 Antibodies) and DHCR7)

  7. rs3829251 (DHCR7) influenced progression of subclinical atherosclerosis in a manner dependent on type 2 diabetes status but independent of 25(OH)D levels. The SNP modulates DHCR7 mRNA levels in aortic adventitia.

  8. NADSYN1 (show NADSYN1 Antibodies)/DHCR7 locus (rs12785878 and rs1790349) polymorphisms have an effect on plasma 25-hydroxyvitamin D levels and coronary artery disease incidence

  9. This study provides evidence that the DHCR7 gene is involved in the susceptibility to ocular Behcet disease.

  10. Data indicate that SNPs in the DHCR7/NADSYN1 (show NADSYN1 Antibodies) locus showed evidence of positive association with rheumatoid arthritis (RA).

DHCR7 Antigen Profile

Protein Summary

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS)\; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with DHCR7

  • 7-dehydrocholesterol reductase (DHCR7) antibody
  • 7-dehydrocholesterol reductase (dhcr7) antibody
  • 7-dehydrocholesterol reductase (DWF5) antibody
  • 7-dehydrocholesterol reductase (PAAG_04766) antibody
  • 7-dehydrocholesterol reductase (PITG_13128) antibody
  • 7-dehydrocholesterol reductase (VDBG_05423) antibody
  • 7-dehydrocholesterol reductase (MGYG_00712) antibody
  • 7-dehydrocholesterol reductase (TERG_00580) antibody
  • 7-dehydrocholesterol reductase (Dhcr7) antibody
  • 7-Dhcr antibody
  • 7-STEROL DELTA7 REDUCTASE antibody
  • 7RED antibody
  • AA409147 antibody
  • DELTA5 antibody
  • DKFZp468C1911 antibody
  • DWARF 5 antibody
  • F11F12.21 antibody
  • F11F12_21 antibody
  • LE antibody
  • LEPIDA antibody
  • MGC64361 antibody
  • PA antibody
  • PARVA antibody
  • SLOS antibody
  • ST7R antibody
  • STEROL DELTA7 REDUCTASE antibody
  • xdhcr7 antibody

Protein level used designations for DHCR7

7-DHC reductase , sterol Delta(7)-reductase , 7-dehydrocholesterol reductase , delta-7-dehydrocholesterol reductase , putative sterol reductase SR-2 , sterol delta-7-reductase

GENE ID SPECIES
100061433 Equus caballus
378446 Danio rerio
380248 Xenopus laevis
394844 Xenopus (Silurana) tropicalis
841465 Arabidopsis thaliana
9096525 Paracoccidioides sp. 'lutzii' Pb01
9472946 Phytophthora infestans T30-4
9531294 Verticillium alfalfae VaMs.102
10031944 Arthroderma gypseum CBS 118893
10374056 Trichophyton rubrum CBS 118892
100172090 Pongo abelii
13360 Mus musculus
64191 Rattus norvegicus
1717 Homo sapiens
422982 Gallus gallus
483675 Canis lupus familiaris
514745 Bos taurus
379273 Xenopus laevis
Selected quality suppliers for anti-DHCR7 (DHCR7) Antibodies
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