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A Disintegrin and Metallopeptidase Domain 8 Proteins (ADAM8)

ADAM8 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Additionally we are shipping ADAM8 Kits (26) and ADAM8 Antibodies (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAM8 11501 Q05910
ADAM8 101 P78325
Rat ADAM8 ADAM8 309098  
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Top ADAM8 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$841.50
Details

ADAM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for A Disintegrin and Metallopeptidase Domain 8 (ADAM8) Interaction Partners

Mouse (Murine) A Disintegrin and Metallopeptidase Domain 8 (ADAM8) interaction partners

  1. The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice

  2. ADAM8 mediates an enhanced invasiveness of neutrophils into injured muscle fibers by the removal of their adhesiveness to blood vessels after infiltration into interstitial tissues.

  3. ADAM8 has anti-inflammatory activities during allergic airway inflammation in mice

  4. overexpression of PrP(C (show PRNP Proteins)) led to up-regulation of ADAM8, suggesting that PrP(C (show PRNP Proteins)) may regulate its own alpha-cleavage through modulating ADAM8 activity.

  5. ADAM-8 appears to favour allergen-induced acute airway inflammation by promoting dendritic cell recruitment and CCL11 and CCL22 (show CCL22 Proteins) production.

  6. ADAM8 knockout mice did not display a bone phenotype in vivo but they did not increase RANKL (show TNFSF11 Proteins) production, OCL (show OCLN Proteins) formation, or calvarial fibrosis in response to tumor necrosis factor alpha (TNF-alpha (show TNF Proteins)) in vivo.

  7. ADAM8 is involved in T cell maturation in the medulla but has a relatively minor impact on T cell development.

  8. The results of this study indicated an essential role for ADAM8 in modulating TNF-alpha (show TNF Proteins) signaling in CNS diseases

  9. The study finds an increase in retinal re-vascularization but fewer neovascular tufts in the oxygen-induced retinopathy model and increased growth of heterotopically injected tumor cells in Adam8-/- mice compared with wild-type controls.

  10. ADAM8 plays a proinflammatory role in airway inflammation.

Human A Disintegrin and Metallopeptidase Domain 8 (ADAM8) interaction partners

  1. miR (show MLXIP Proteins)-720 is elevated in serum of patients with ADAM8-high TNBC and, in a group with other miRNAs downstream of ADAM8, holds promise as a biomarker for early detection of or treatment response of ADAM8-positive triple-negative breast cancer

  2. ADAM8 causes temozolomide resistance in glioblastoma cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met

  3. ADAM8 promotes GC cell proliferation and invasion, and its expression is positively correlated with poor survival, indicating that it might be a promising target in GC therapy

  4. ADAM8 expression is associated with increased migration and invasiveness of pancreatic ductal adenocarcinoma cells.

  5. ADAM8 and endostatin (show COL18A1 Proteins) play a role in osteosarcoma progression.

  6. Data indicate that fibronectin (show FN1 Proteins) fragments (FN-fs) are present in adult ntervertebral disc (IVD (show IVD Proteins)) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells.

  7. Results show that ADAM8 is overexpressed in colorectal cancer and promotes cell growth.

  8. N-glycosylation is essential for processing, localization, stability, and activity of ADAM8.

  9. ADAM8 expression is increased in both severe asthma and COPD (show ARCN1 Proteins) and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD (show ARCN1 Proteins).

  10. ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue.

ADAM8 Protein Profile

Protein Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ADAM8

  • a disintegrin and metalloproteinase domain 8a (adam8a)
  • ADAM metallopeptidase domain 8 (ADAM8)
  • a disintegrin and metalloproteinase domain 8 (adam8)
  • a disintegrin and metallopeptidase domain 8 (Adam8)
  • tubulin, gamma complex associated protein 2 (Tubgcp2)
  • Adam8 protein
  • CD156 protein
  • CD156a protein
  • E430039A18Rik protein
  • MS2 protein
  • reprolysin protein
  • si:zc217g15.7 protein
  • zgc:64059 protein

Protein level used designations for ADAM8

CD156a , a disintegrin and metalloproteinase domain 8 , disintegrin and metalloproteinase domain-containing protein 8 , metalloprotease , ADAM metallopeptidase domain 8 , disintegrin and metalloproteinase domain-containing protein 8-like , ADAM 8 , a disintegrin and metalloprotease domain (ADAM) 8 , a disintegrin and metalloprotease domain 8 , cell surface antigen MS2 , macrophage cysteine-rich glycoprotein , human leukocyte differentiation antigen , gamma-tubulin complex component 2

GENE ID SPECIES
368917 Danio rerio
423672 Gallus gallus
100156146 Sus scrofa
100303713 Ictalurus punctatus
100393217 Callithrix jacchus
100428452 Macaca mulatta
100471554 Ailuropoda melanoleuca
11501 Mus musculus
101 Homo sapiens
309098 Rattus norvegicus
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