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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. Additionally we are shipping AKAP4 Proteins (4) and AKAP4 Kits (1) and many more products for this protein.
Showing 10 out of 32 products:
Mouse (Murine) Monoclonal AKAP4 Primary Antibody for IF, WB - ABIN968592
Edwards, Scott: A-kinase anchoring proteins: protein kinase A and beyond. in Current opinion in cell biology 2000
Show all 4 Pubmed References
Human Polyclonal AKAP4 Primary Antibody for IHC, IHC (p) - ABIN4278924
Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: The human testis-specific proteome defined by transcriptomics and antibody-based profiling. in Molecular human reproduction 2014
AKAP4 appears to be a novel Colorectal cancer-associated antigen with a potential for developing as a new clinical therapeutic target
AKAP4 is a highly accurate biomarker for the detection of early stage lung cancer.
SP17 (show SPA17 Antibodies)/AKAP4/PTTG1 (show PTTG1 Antibodies) are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients.
The putative role of AKAP4 in early tumorigenesis is implicated as a biomarker and immunotherapeutic target for cervical cancer.
Ablation of AKAP4 protein caused significant inhibition in cellular proliferation, colony-forming ability, migration and invasion ability of tumor cells.
data suggests that AKAP4 may be used as serum based diagnostic test for an early detection and diagnosis of breast cancer and may be a potential target for immunotherapeutic use
We demonstrate the aberrant expression of AKAP-4 in prostate cancer, which will potentially be developed as a biomarker in prostate cancer.
AKAP4 is a novel target for protein S-nitrosylation in spermatozoa.
Role of AKAP4 in sperm motility is unclear, vut absent or weak AKAP4-labelling is associated with absent or weak sperm. motility.
we validated the use of AKAP-4 antigen to track tumor growth in vivo and to specifically identify MM cells in mouse tissues.
Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.
AKAP4 has a major role in completing fibrous sheath assembly
the distribution of AKAP4 was dependent on the microtubular cytoskeleton.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
A-kinase anchor protein 4
, A kinase (PRKA) anchor protein 4
, A-kinase anchor protein 82 kDa
, cancer/testis antigen 99
, major sperm fibrous sheath protein
, protein kinase A anchoring protein 4
, protein kinase A-anchoring protein 4
, testis-specific gene HI
, AKAP 82
, 75 kDa fibrous sheath protein