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ABI3 encodes a member of an adaptor protein family. Additionally we are shipping ABI3 Proteins (6) and many more products for this protein.
Showing 10 out of 24 products:
Mouse (Murine) Polyclonal ABI3 Primary Antibody for WB - ABIN1881513
Ichigotani, Yokozaki, Fukuda, Hamaguchi, Matsuda: Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. in Cancer research 2002
Show all 2 references for ABIN1881513
Result links ABI3 to the pathogenesis and progression of some cancers and suggests that ABI3 or its pathway might have interest as therapeutic target.
Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
NESH (Abi-3), like Abi-1 (show ABI1 Antibodies) and Abi-2 (show ABI2 Antibodies), is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Antibodies).
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1 (show ABI1 Antibodies), which led to the formation of a NESH/Abi-3-based WAVE2 (show WASF2 Antibodies) complex.
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.
ABI gene family member 3
, ABI gene family, member 3
, new molecule including SH3
, NESH protein