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ADAM Metallopeptidase Domain 15 Proteins (ADAM15)

The protein encoded by ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. Additionally we are shipping ADAM15 Antibodies (75) and ADAM15 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAM15 11490 O88839
ADAM15 8751 Q13444
ADAM15 57025 Q9QYV0
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Top ADAM15 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_CHO Cells Human His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,386.17
Details

ADAM15 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
,
Human , , , ,
, ,
Rat (Rattus)

Top referenced ADAM15 Proteins

  1. Human ADAM15 Protein expressed in Human Cells - ABIN2002991 : Herren, Garton, Coats, Bowen-Pope, Ross, Raines: ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions. in Experimental cell research 2001 (PubMed)
    Show all 5 references for ABIN2002991

  2. Mouse (Murine) ADAM15 Protein expressed in Human Cells - ABIN2008502 : Poghosyan, Robbins, Houslay, Webster, Murphy, Edwards: Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN2008502

  3. Human ADAM15 Protein expressed in CHO Cells - ABIN2002993 : Pogodina: Elizaveta Nilolaevna Levkovich-75th birthday. in Acta virologica 1976 (PubMed)
    Show all 2 references for ABIN2002993

More Proteins for ADAM Metallopeptidase Domain 15 (ADAM15) Interaction Partners

Rabbit ADAM Metallopeptidase Domain 15 (ADAM15) interaction partners

  1. ADAM15 attenuates the progression of atherosclerosis; in contrast, a mutated form of ADAM15, created by ablation of the protease function, has no significant effect on atherosclerosis.

Mouse (Murine) ADAM Metallopeptidase Domain 15 (ADAM15) interaction partners

  1. findings indicated that silencing ADAM15 had antiinflammatory effects in FLSs and efficiently inhibited the development of CIA (show NCOA5 Proteins).

  2. the catalytic activity of ADAM15 is not crucial for its function in promoting pathological neovascularization in the mouse OIR model, most likely because of the very limited substrate repertoire of ADAM15.

  3. ADAM15 upregulation contributes to inflammatory lung injury by promoting endothelial hyperpermeability and neutrophil transmigration.

  4. A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src (show SRC Proteins) family kinase activity.

  5. Adult Adam15(-/-) mice displayed an increase in bone volume and thickness with an increase in the number and activity of osteoblasts, whereas osteoclasts were apparently unaffected.

  6. ADAM15 has a role in pathological neovascularization in mice

  7. cytoplasmic domain of ADAM15v2 strongly interacts with Lck (show LCK Proteins) and plays an important role in T lymphocytes

  8. The accelerated development of murine osteoarthritis in ADAM15 deficiency and the proadhesive and cell survival-promoting in vitro effect of ADAM15 overexpression suggest a homeostatic role of ADAM15 in cartilage remodeling.

  9. observations suggest that a disintegrin and metalloproteinase (ADAM)-8 (show ADAM8 Proteins),-9,-10,-12,-15,and -17 play an important role in mouse uterine tissue remodelling during the oestrous cycle

  10. found modest expression of ADAM15 in pericytes in normal retina and strong up-regulation of ADAM15 in retinal vascular endothelial cells in ischemic retina

Human ADAM Metallopeptidase Domain 15 (ADAM15) interaction partners

  1. ADAM15 promotes lung cancer cell invasion through directly targeting MMP9 (show MMP9 Proteins) activation.

  2. the results revealed an undescribed role of ADAM15 in the invasion of human bladder cancer and suggested that the ADAM15 catalytic domain may represent a viable therapeutic target in patients with advanced disease.

  3. present a tumor suppressive mechanism for ADAM15 exosomes and provide insight into the functional significance of exosomes that generate tumor-inhibitory factors

  4. these data suggest the potential role of miR147b in regulating endothelial barrier function by targeting ADAM15 expression.

  5. findings indicated that silencing ADAM15 had antiinflammatory effects in FLSs and efficiently inhibited the development of CIA (show ASF1A Proteins).

  6. The severity of intrauterine adhesions positively correlates to the protein and transcript expression levels of ADAM-15 and ADAM-17 (show ADAM17 Proteins) in uterine tissue.

  7. ADAM15 contributes to apoptosis resistance in rheumatoid arthritis synovial fibroblasts by activating the Src (show SRC Proteins)/FAK (show PTK2 Proteins) pathway upon FasL (show FASL Proteins) exposure.

  8. ADAM15 acts as a negative regulator of TRIF (show TRIM69 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) and IFN-beta (show IFNB1 Proteins) reporter gene activity via TLR3 (show TLR3 Proteins) and TLR4 (show TLR4 Proteins) signaling.

  9. Exosomes rich in ADAM15 display enhanced binding affinity for integrin alphavbeta3 (show ITGAV Proteins) in an RGD-dependent manner and suppress vitronectin (show VTN Proteins)- and fibronectin (show FN1 Proteins)-induced cell adhesion, growth, and migration, as well as in vivo tumor growth.

  10. ADAM15 tail can transduce a percepted extracellular signal to enhance FAK (show PTK2 Proteins) and Src (show SRC Proteins) phosphorylation.

ADAM15 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with ADAM15

  • ADAM metallopeptidase domain 15 (ADAM15)
  • ADAM metallopeptidase domain 15 (adam15)
  • a disintegrin and metallopeptidase domain 15 (metargidin) (Adam15)
  • ADAM metallopeptidase domain 15 (Adam15)
  • ADAM15 protein
  • MDC15 protein
  • metargidin protein
  • tMDCVI protein

Protein level used designations for ADAM15

ADAM metallopeptidase domain 15 , a disintegrin and metalloproteinase domain 15 , metalloproteinase ADAM15 , disintegrin and metalloproteinase domain-containing protein 15-like , AD56 , ADAM 15 , MDC-15 , a disintegrin and metalloprotease domain 15 (metargidin) , a disintegrin and metalloproteinase domain 15 (metargidin) , disintegrin and metalloprotease 15 , disintegrin and metalloproteinase domain-containing protein 15 , metalloprotease RGD disintegrin protein , metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 , CRII-7 , a disintegrin and metallopeptidase domain 15 (metargidin) , metargidin , tMDC VI

GENE ID SPECIES
457354 Pan troglodytes
490434 Canis lupus familiaris
100101326 Xenopus laevis
100145641 Xenopus (Silurana) tropicalis
100339079 Oryctolagus cuniculus
100393011 Callithrix jacchus
100468507 Ailuropoda melanoleuca
11490 Mus musculus
8751 Homo sapiens
784605 Bos taurus
57025 Rattus norvegicus
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