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ADAM22 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Additionally we are shipping ADAM22 Proteins (7) and ADAM22 Kits (4) and many more products for this protein.
Showing 10 out of 104 products:
Human Monoclonal ADAM22 Primary Antibody for ICC, IF - ABIN2483658
Sagane, Ohya, Hasegawa, Tanaka: Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. in The Biochemical journal 1998
LGI1 (show LGI1 Antibodies) and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 (show DLG4 Antibodies)
Interaction proteomics revealed the interactors of Caspr2 (show CNTNAP2 Antibodies), including CNTN2 (show CNTN2 Antibodies), KCNAs, members of the ADAM family (ADAM22, ADAM23 (show Adam23 Antibodies) and ADAM11 (show ADAM11 Antibodies)), members of LGI family and MAGUKs (DLGs and MPPs (show MPHOSPH6 Antibodies)).
ADAM22 is an axonal component of the Kv1 (show KCNA5 Antibodies) K+ channel (show KCNC4 Antibodies) complex that recruits membrane-associated guanylate kinase (show GUK1 Antibodies) to juxtaparanodes
ADAM22 is closely involved in the correct functioning of the nervous system.
study identified LGI1 (show LGI1 Antibodies) as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 (show LGI1 Antibodies) and ADAM22
Disruption of LGI1 (show LGI1 Antibodies)-ADAM22 interaction reduces synaptic AMPA (show GRIA3 Antibodies) receptors in hippocampal neurons.
Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
findings suggest that SRC-1 (show SRC Antibodies) switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 (show SRC Antibodies) target gene ADAM22 has a critical role
Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4 (show LGI4 Antibodies)-binding abilities resulting in epilepsy.
Transgenic leucine-rich glioma-inactivated 4 (Lgi4 (show LGI4 Antibodies)) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 (show LGI4 Antibodies) to axonal Adam22 is required on axons to drive myelin formation.
role for the 14-3-3zeta (show YWHAZ Antibodies)/ADAM 22 association in the regulation of cell adhesion and related signaling events
demonstrated a functional role for ADAM22/14-3-3 (show YWHAQ Antibodies) in cell adhesion and spreading
ADAM22, a brain-specific (show CALY Antibodies) cell surface protein (show CD28 Antibodies), mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas.
This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome.
Differential coding potential of ADAM22 mRNAs.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
a disintegrin and metalloprotease domain (ADAM) 22
, disintegrin and metalloproteinase domain-containing protein 22
, a disintegrin and metalloprotease domain 22
, a disintegrin and metalloproteinase domain 22
, metalloproteinase-disintegrin ADAM22-3
, metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
, ADAM 22
, metalloprotease-disintegrin MDC11b
, metalloprotease/disintegrin xMDC11.2