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ADAMTS1 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Additionally we are shipping ADAMTS1 Kits (44) and ADAMTS1 Proteins (20) and many more products for this protein.
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TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN Antibodies) and Vcan (show Vcan Antibodies) by an ADAMTS other than TS5.
Data suggest that ADAMTS-5 (show ADAMTS5 Antibodies) oligomerization is required for full aggrecanase (show ADAMTS4 Antibodies) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 (show ADAMTS5 Antibodies) activity.
The resilience of casp1 (show CASP1 Antibodies)(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 gene expression.
Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT (show NFATC1 Antibodies) or C/EBPbeta (show CEBPB Antibodies) transcription factors.
aggrecan (show ACAN Antibodies) and brevican (show BCAN Antibodies) proteolysis is compensated in Adamts4 (show ADAMTS4 Antibodies)-/- or Adamts5 (show ADAMTS5 Antibodies)-/- mice by ADAMTS proteoglycanase (show MMP3 Antibodies) family members but a threshold of versican (show Vcan Antibodies) proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase (show MMP3 Antibodies) during spinal cord injury
The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Antibodies)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
Western blot analyses indicated that aggrecanase (show ADAMTS4 Antibodies)-generated proteoglycan (show Vcan Antibodies) fragments are produced after SCI.
RelA/p65 (show NFkBP65 Antibodies) is a potent transcriptional activator of ADAMTS5 (show ADAMTS5 Antibodies) in chondrocytes during osteoarthritis development.
Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5 (show ADAMTS5 Antibodies).
this study identified, for the first time, several genes that have an ADAMTS-5 (show ADAMTS5 Antibodies)-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.
progesterone acts via the progesterone receptor (show PGR Antibodies) to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines.
Data suggest that the rs416905 and rs402007 single nucleotide polymorphisms of the a disintegrin and metallo-proteinase with thrombospondin type 1 motifs (ADAMTS-1) gene may be associated with ischemic stroke caused by large artery atherosclerosis (LAA).
Results show that ADAMTS1 expression is negatively regulated in breast neoplasm cells due to mir (show MLXIP Antibodies)-365 targeting its 3'UTR (show UTS2R Antibodies).
The aberrant methylation of ADAMTS1 may be involved in the development and progression of gastric cancer.
Ectopic expression of SP1 (show PSG1 Antibodies) and USF transcription factors resulted in the decrease in ADAMTS1 transcriptional activity of all promoter constructs
single-nucleotide missense mutation in the ADAMTS1 gene (c. 742I>T) was found to segregate in the family, given that the affected individuals must be heterozygous for the mutation
Data show that ADAMTS1 was expressed at a significantly higher level in extravillous trophoblast cells (EVTs) than in villous trophoblast cells (VTs), while both ADAM10 (show ADAM10 Antibodies) and ADAM12 (show ADAM12 Antibodies) were expressed at significantly higher levels in VTs than in EVTs.
Dysregulated expression of ADAMTS-1 in polycystic ovary syndrome may influence oocyte quality-via Granulosa cells-oocyte paracrine and endocrine mechanism.
ADAMTS1 formed a complex with VEGFC (show VEGFC Antibodies), attenuated VEGFR3 (show FLT4 Antibodies) phosphorylation and inhibited lymphangiogenesis in vitro.
We have demonstrated that the expression of ADAMTS-1, -4 and -5 is induced during the differentiation of monocytes into macrophages.
Expression and induction of ADAMTS-1 through receptor-mediated action of progesterone in cumulus cells is one of essential requirements for gonadotropin-regulated cumulus expansion of porcine cumulus-oocyte complexes.
study indicates that disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) participates in bovine endometrial remodeling
Data indicate that ADAMTS1 promoter activity and mRNA expression were increased by forskolin and human chorionic gonadotropin.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
metalloproteinase with thrombospondin-like motifs-1
, ADAM metallopeptidase with thrombospondin type 1 motif, 1
, A disintegrin and metalloproteinase with thrombospondin motifs 1
, ADAM-TS 1
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, human metalloproteinase with thrombospondin type 1 motifs
, a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
, a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1