ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 Proteins (ADAMTS13)

ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Additionally we are shipping ADAMTS13 Antibodies (100) and ADAMTS13 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAMTS13 279028 Q769J6
ADAMTS13 11093 Q76LX8
Rat ADAMTS13 ADAMTS13 362091  
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Top ADAMTS13 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 15 to 18 Days
$835.00
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ADAMTS13 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.

  2. ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF (show VWF Proteins)-dependent intrarenal thrombosis.

  3. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA (show PLAT Proteins)-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Proteins) patency and consequently reduced cerebral infarct sizes

  4. Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

  5. Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

  6. Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

  7. ADAMTS13 substrate specificity

  8. Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

  9. Data show that metalloendopeptidase (show THOP1 Proteins) ADAMTS13 does not directly promote development of adipose tissue.

  10. findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF (show VWF Proteins) axis in atherosclerosis

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. ADAMTS13 activity appears to be an independent risk factor for incident prediabetes and type 2 diabetes.

  2. both anti-ADAMTS13 IgG antibody and ADAMTS13 antigen levels correlate with outcome in thrombotic thrombocytopenic purpura with increased cardiac and neurological involvement and increased mortality.

  3. Low ADAMTS-13 levels correlated with high levels of NTproBNP but had no independent prognostic significance. In conclusion, high VWF:Ag levels, probably representing endothelial dysfunction, are associated with prognosis in patients with AL amyloidosis, independently of other features of the disease or cardiac biomarkers.

  4. findings highlight the complexity of glycan modifications on ADAMTS13, which may have implications for its interaction with immune- or clearance receptors containing carbohydrate recognition domains.

  5. ADAMTS-13 levels are decreased in plasma of AML (show RUNX1 Proteins) patients and the level of ADAMTS-13 is related to inflammation and infection of AML (show RUNX1 Proteins) patients. Besides, low ADAMTS-13 level is one potential risk factor for AML (show RUNX1 Proteins)

  6. these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 activity, likely by binding to the central A2 domain of VWF (show VWF Proteins) and physically blocking ADAMTS13 binding.

  7. Three Single Nucleotide Variants (p.Val154Ile, p.Asp187His and p.Arg421Cys) showed reduced ex vivo and in vitro ADAMTS13 levels. However, the low frequency of these variants makes it difficult to confirm their association with Deep Vein Thrombosis.

  8. ADAMTS13 activity and VWF:Ag levels are both associated with an increased risk of all-cause and cardiovascular mortality.

  9. These findings support an ADAMTS13 activation model in which VWF (show VWF Proteins) D4-CK engages the TSP8-CUB2 domains, inducing the conformational change that disrupts the CUB1-spacer domain interaction and thereby activates ADAMTS13

  10. Three cases of systemic lupus erythematosus with ADAMTS13 inhibitor-negative thrombotic microangiopathy were successfully treated with combination of mycophenolate mofetil, plasma exchange and steroid. [case reports]

ADAMTS13 Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Gene names and symbols associated with ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (LOC100226372)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 12 (ADAMTS12)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13)
  • ADAM-TS13 protein
  • ADAMTS-13 protein
  • ADAMTS12 protein
  • ADAMTS13 protein
  • C9orf8 protein
  • Gm710 protein
  • vWF-CP protein
  • VWFCP protein

Protein level used designations for ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif, 13 , ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like , A disintegrin and metalloproteinase with thrombospondin motifs 13-like , ADAM metallopeptidase with thrombospondin type 1 motif, 12 , A disintegrin and metalloproteinase with thrombospondin motifs 12 , A disintegrin and metalloproteinase with thrombospondin motifs 13 , ADAM-TS 13 , ADAM-TS13 , ADAMTS-13 , ADAMTS13 isoform IAP-b , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , vWF-CP mRNA for von Willebrand factor-cleaving , vWF-cleaving protease , von Willebrand factor-cleaving protease , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

GENE ID SPECIES
100069281 Equus caballus
100320289 Danio rerio
100404947 Callithrix jacchus
100481099 Ailuropoda melanoleuca
100226372 Taeniopygia guttata
427428 Gallus gallus
461952 Pan troglodytes
479369 Canis lupus familiaris
525276 Bos taurus
701750 Macaca mulatta
100068281 Equus caballus
279028 Mus musculus
11093 Homo sapiens
100630922 Canis lupus familiaris
532272 Bos taurus
362091 Rattus norvegicus
100343027 Oryctolagus cuniculus
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