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ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Proteins (ADAMTS18)

ADAMTS18 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Antibodies (37) and ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAMTS18 208936 Q4VC17
ADAMTS18 170692 Q8TE60
Rat ADAMTS18 ADAMTS18 361412  
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Top ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ADAMTS18 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) interaction partners

  1. these data demonstrate a thrombin (show F2 Proteins) cleavage site and confirm a short form of ADAMTS-18 presents in vivo.

  2. Adamts18 is expressed in the lens and retina in the developing murine eye.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) interaction partners

  1. Studies suggest that ADAM metallopeptidase (show ECEL1 Proteins) with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target.

  2. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers

  3. Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia.

  4. study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases

  5. the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation.

  6. ADAMTS18 mutations promote growth, migration, and metastasis in melanoma

  7. ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM (show ODZ1 Proteins) staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis.

  8. comparison of the effects of C-terminal truncation on the GAG-binding properties and aggrecanase (show ADAMTS4 Proteins) activity of ADAMTS-5 (show ADAMTS5 Proteins) relative to three other ADAMTS (show ADAMTS13 Proteins) family members, ADAMTS-9, ADAMTS-16 and ADAMTS-18

  9. Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas.

  10. ADAMTS18 and TGFBR3 (show TGFBR3 Proteins) might underlie BMD (show BEST1 Proteins) determination in the major human ethnic groups.

ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

Gene names and symbols associated with ADAMTS18

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 (Adamts18)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18 (ADAMTS18)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18 (Adamts18)
  • 9630038L21 protein
  • ADAMTS21 protein
  • E130314N14Rik protein
  • KNO2 protein
  • RGD1560118 protein

Protein level used designations for ADAMTS18

A disintegrin and metalloproteinase with thrombospondin motifs 18 , ADAM-TS 18 , ADAM-TS18 , ADAMTS-18 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21 , disintegrin and metalloprotease-like protein , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18

GENE ID SPECIES
208936 Mus musculus
100858277 Gallus gallus
170692 Homo sapiens
518395 Bos taurus
361412 Rattus norvegicus
101118979 Ovis aries
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