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ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Kits (31) and ADAMTS5 Proteins (8) and many more products for this protein.
Showing 10 out of 113 products:
Human Polyclonal ADAMTS5 Primary Antibody for EIA, WB - ABIN359611
Abbaszade, Liu, Yang, Rosenfeld, Ross, Link, Ellis, Tortorella, Pratta, Hollis, Wynn, Duke, George, Hillman, Murphy, Wiswall, Copeland, Decicco, Bruckner, Nagase, Itoh, Newton, Magolda, Trzaskos, Burn: Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. in The Journal of biological chemistry 1999
Show all 2 references for ABIN359611
Mouse (Murine) Polyclonal ADAMTS5 Primary Antibody for WB - ABIN391652
Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000
Show all 2 references for ABIN391652
TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN Antibodies) and Vcan (show Vcan Antibodies) by an ADAMTS (show ADAMTS1 Antibodies) other than TS5.
Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 Antibodies) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.
aggrecan (show ACAN Antibodies) and brevican (show BCAN Antibodies) proteolysis is compensated in Adamts4 (show ADAMTS4 Antibodies)-/- or Adamts5-/- mice by ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) family members but a threshold of versican (show Vcan Antibodies) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) during spinal cord injury
The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Antibodies)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
Western blot analyses indicated that aggrecanase (show ADAMTS4 Antibodies)-generated proteoglycan (show Vcan Antibodies) fragments are produced after SCI.
RelA/p65 (show NFkBP65 Antibodies) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.
Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.
this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.
The serine protease (show F2 Antibodies) tissue plasminogen activator (tPA (show PLAT Antibodies)) and two matrix metalloproteinases, ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5, were identified as Reelin (show RELN Antibodies) cleaving enzymes.
Versican (show Vcan Antibodies) processing by ADAMTS5 and ADAMTS15 (show ADAMTS15 Antibodies) contribute to muscle fiber formation.
Increased ADAMTS5 levels were observed in placental insufficiency cases.
ADAMTS5 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS5 protein expression.
Overexpression of ADAMTS5 is associated with migration and invasion of non-small cell lung cancer.
ADAMTS5 rs2380585 polymorphism contributes to hepatocellular carcinoma susceptibility in a Chinese Han population
The findings of our study suggest that hsamiR15a exerts protective effects against osteoarthritis by targeting ADAMTS5 in human chondrocytes.
Evaluate ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5 immunohistochemical expression in human TMJ discs from patients affected by internal derangement.
The data showed that the expression of ADAMTS5 was reduced in HCC (show FAM126A Antibodies), which was inversely associated with VEGF (show VEGFA Antibodies) expression, MVD (show MVD Antibodies), and tumor size and associated with poor overall survival of HCC (show FAM126A Antibodies) patients.
These data demonstrate that the antibody is specific to ADAMTS4 (show ADAMTS4 Antibodies) and ADAMTS5 and inhibits their aggrecanase (show ADAMTS4 Antibodies) activity at molecular and cellular levels.
Western blot analysis of endogenous ADAMTS-5 expressed by human chondrocytes showed the presence largely of truncated forms of ADAMTS-5, thus explaining the lack of efficacy of the anti-Sp antibody.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (show ADAMTS4 Antibodies)) explains the minor contribution of the MMP enzymes to aggrecan (show ACAN Antibodies) catabolism in vivo.
ADAMTS4 (show ADAMTS4 Antibodies) and ADAMTS5 are inhibited by alpha2-macroglobulin (show A2M Antibodies)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
ADAM metallopeptidase with thrombospondin type 1 motif, 5
, a disintegrin and metalloproteinase with thrombospondin motifs 5-like
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, a disintegrin and metalloproteinase with thrombospondin motifs 11
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)