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anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Antibodies

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Kits (36) and ADAMTS5 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Top anti-ADAMTS5 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscl... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated WB Western blot analysis of anti-ADAMTS5 Antibody (Center) (ABIN391652) i... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of cartilage using anti-ADAMTS5 antibody ... 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB ADAMTS5 Antibody (N-term) (ABIN657768) western blot analysis in K562 c... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xen... WB Image Sample (30 ug of whole cell lysate) A: JC 7.5% SDS PAGE antib... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p) Anti-ADAMTS5 antibody  ABIN1048292 IHC staining of human placenta. Imm... 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-ADAMTS5 antibody  ABIN1048295 IHC staining of human cartilage. Im... 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-ADAMTS5 antibody, IHC(P) IHC(P): Rat Brain Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit A... Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Ant... 100 μL Log in to see 3 to 7 Days
$269.50
Details

ADAMTS5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,

Human , , , ,
, ,
Rat (Rattus) , , , ,

Top referenced anti-ADAMTS5 Antibodies

  1. Human Polyclonal ADAMTS5 Primary Antibody for EIA, WB - ABIN359611 : Abbaszade, Liu, Yang, Rosenfeld, Ross, Link, Ellis, Tortorella, Pratta, Hollis, Wynn, Duke, George, Hillman, Murphy, Wiswall, Copeland, Decicco, Bruckner, Nagase, Itoh, Newton, Magolda, Trzaskos, Burn: Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. in The Journal of biological chemistry 1999 (PubMed)
    Show all 2 references for ABIN359611

  2. Mouse (Murine) Polyclonal ADAMTS5 Primary Antibody for WB - ABIN391652 : Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN391652

More Antibodies against ADAMTS5 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN Antibodies) and Vcan (show Vcan Antibodies) by an ADAMTS (show ADAMTS1 Antibodies) other than TS5.

  2. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 Antibodies) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  3. aggrecan (show ACAN Antibodies) and brevican (show BCAN Antibodies) proteolysis is compensated in Adamts4 (show ADAMTS4 Antibodies)-/- or Adamts5-/- mice by ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) family members but a threshold of versican (show Vcan Antibodies) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Antibodies) proteoglycanase (show MMP3 Antibodies) during spinal cord injury

  4. The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Antibodies)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  5. Western blot analyses indicated that aggrecanase (show ADAMTS4 Antibodies)-generated proteoglycan (show Vcan Antibodies) fragments are produced after SCI.

  6. RelA/p65 (show NFkBP65 Antibodies) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  7. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

  8. this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.

  9. The serine protease (show F2 Antibodies) tissue plasminogen activator (tPA (show PLAT Antibodies)) and two matrix metalloproteinases, ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5, were identified as Reelin (show RELN Antibodies) cleaving enzymes.

  10. Versican (show Vcan Antibodies) processing by ADAMTS5 and ADAMTS15 (show ADAMTS15 Antibodies) contribute to muscle fiber formation.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 Antibodies) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  2. These data demonstrate that the antibody is specific to ADAMTS4 (show ADAMTS4 Antibodies) and ADAMTS5 and inhibits their aggrecanase (show ADAMTS4 Antibodies) activity at molecular and cellular levels.

  3. Western blot analysis of endogenous ADAMTS-5 expressed by human chondrocytes showed the presence largely of truncated forms of ADAMTS-5, thus explaining the lack of efficacy of the anti-Sp antibody.

  4. We conclude that the upregulation of TNF-alpha (show TNF Antibodies) and ADAMTS-5, but not ADAMTS-4 (show ADAMTS4 Antibodies), may play an important role in degenerative cartilage endplate-induced low back pain.

  5. The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Antibodies)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  6. The ADAMTS5 ancillary domain and specific chondroitin sulfate chains of versican (show Vcan Antibodies) are required for proteolysis.

  7. The restricted expression of ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS (show ADAMTS13 Antibodies) subtypes are associated with human placentation and the development of gestational trophoblastic diseases.

  8. psiepsilonRACK induced upregulation of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-377 expression, coupled to decreases in ADAMTS5 and cleaved aggrecan (show ACAN Antibodies)

  9. No ADAMTS5 rs226794 genotype variant effects are found in association with ATP in two independent populations.

  10. This study highlights that the affinity between a ligand and LRP1 (show LRP1 Antibodies) dictates the rate of internalization and suggests that LRP1 (show LRP1 Antibodies) is a major traffic controller of the two aggrecanases, especially under inflammatory conditions, where the protein levels of ADAMTS-4 (show ADAMTS4 Antibodies) increase, but those of ADAMTS-5 do not.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (show ADAMTS4 Antibodies)) explains the minor contribution of the MMP enzymes to aggrecan (show ACAN Antibodies) catabolism in vivo.

  2. ADAMTS4 (show ADAMTS4 Antibodies) and ADAMTS5 are inhibited by alpha2-macroglobulin (show A2M Antibodies)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (adamts5) antibody
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) antibody
  • 9530092O11Rik antibody
  • ADAM-TS5 antibody
  • ADAM-TS 5 antibody
  • ADAM-TS 11 antibody
  • ADAMTS-5 antibody
  • ADAMTS-11 antibody
  • ADAMTS1 antibody
  • ADAMTS11 antibody
  • ADMP-2 antibody
  • AI481094 antibody
  • ASMP-2 antibody

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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