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ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 Proteins (ADAMTS5)

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS5 Antibodies (107) and ADAMTS5 Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
Rat ADAMTS5 ADAMTS5 304135  
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Top ADAMTS5 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Human His tag 5 μg Log in to see 5 to 6 Days
$348.42
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,508.00
Details

ADAMTS5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (show ACAN Proteins) and Vcan (show Vcan Proteins) by an ADAMTS (show ADAMTS1 Proteins) other than TS5.

  2. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 Proteins) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  3. aggrecan (show ACAN Proteins) and brevican (show BCAN Proteins) proteolysis is compensated in Adamts4 (show ADAMTS4 Proteins)-/- or Adamts5-/- mice by ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) family members but a threshold of versican (show Vcan Proteins) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) during spinal cord injury

  4. The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Proteins)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  5. Western blot analyses indicated that aggrecanase (show ADAMTS4 Proteins)-generated proteoglycan (show Vcan Proteins) fragments are produced after SCI.

  6. RelA/p65 (show NFkBP65 Proteins) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  7. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

  8. this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.

  9. The serine protease (show F2 Proteins) tissue plasminogen activator (tPA (show PLAT Proteins)) and two matrix metalloproteinases, ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5, were identified as Reelin (show RELN Proteins) cleaving enzymes.

  10. Versican (show Vcan Proteins) processing by ADAMTS5 and ADAMTS15 (show ADAMTS15 Proteins) contribute to muscle fiber formation.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Evaluate ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5 immunohistochemical expression in human TMJ discs from patients affected by internal derangement.

  2. The data showed that the expression of ADAMTS5 was reduced in HCC (show FAM126A Proteins), which was inversely associated with VEGF (show VEGFA Proteins) expression, MVD (show MVD Proteins), and tumor size and associated with poor overall survival of HCC (show FAM126A Proteins) patients.

  3. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (show ADAMTS4 Proteins) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  4. These data demonstrate that the antibody is specific to ADAMTS4 (show ADAMTS4 Proteins) and ADAMTS5 and inhibits their aggrecanase (show ADAMTS4 Proteins) activity at molecular and cellular levels.

  5. Western blot analysis of endogenous ADAMTS-5 expressed by human chondrocytes showed the presence largely of truncated forms of ADAMTS-5, thus explaining the lack of efficacy of the anti-Sp antibody.

  6. We conclude that the upregulation of TNF-alpha (show TNF Proteins) and ADAMTS-5, but not ADAMTS-4 (show ADAMTS4 Proteins), may play an important role in degenerative cartilage endplate-induced low back pain.

  7. The present study reveals ADAMT-5 expression by mast cells(MCs (show SMCP Proteins)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  8. The ADAMTS5 ancillary domain and specific chondroitin sulfate chains of versican (show Vcan Proteins) are required for proteolysis.

  9. The restricted expression of ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS (show ADAMTS13 Proteins) subtypes are associated with human placentation and the development of gestational trophoblastic diseases.

  10. psiepsilonRACK induced upregulation of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-377 expression, coupled to decreases in ADAMTS5 and cleaved aggrecan (show ACAN Proteins)

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (show ADAMTS4 Proteins)) explains the minor contribution of the MMP enzymes to aggrecan (show ACAN Proteins) catabolism in vivo.

  2. ADAMTS4 (show ADAMTS4 Proteins) and ADAMTS5 are inhibited by alpha2-macroglobulin (show A2M Proteins)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (show ADAMTS4 Proteins) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (adamts5)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5)
  • 9530092O11Rik protein
  • ADAM-TS5 protein
  • ADAM-TS 5 protein
  • ADAM-TS 11 protein
  • ADAMTS-5 protein
  • ADAMTS-11 protein
  • ADAMTS1 protein
  • ADAMTS11 protein
  • ADMP-2 protein
  • AI481094 protein
  • ASMP-2 protein

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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