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ARF6 encodes a member of the human ARF gene family, which is part of the RAS superfamily. Additionally we are shipping ADP-Ribosylation Factor 6 Antibodies (81) and ADP-Ribosylation Factor 6 Kits (13) and many more products for this protein.
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Human ARF6 Protein expressed in Escherichia coli (E. coli) - ABIN667279
Amor, Harrison, Kahn, Ringe: Structure of the human ADP-ribosylation factor 1 complexed with GDP. in Nature 1995
Show all 2 references for ABIN667279
We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
The Squamous cell carcinoma of the tongue cell line SCC (show CYP11A1 Proteins)-9, which overexpress Arf6 and AMAP1 (show ASAP1 Proteins), also expressed EPB41L5 (show EPB41L5 Proteins) at high levels to promote invasiveness, whereas the weakly invasive SCC (show CYP11A1 Proteins)-25 cells did not express EPB41L5 (show EPB41L5 Proteins) at notable levels.
both Arf6 activation through GluN2B (show GRIN2B Proteins)-BRAG1 during early development and the transition from BRAG1- to BRAG2 (show IQSEC1 Proteins)-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
results provide evidence for a novel Arf6 activation mechanism by Dyn2 (show DNM2 Proteins) through EFA6B and EFA6D (show PSD3 Proteins) in CME in a manner dependent upon the GTPase (show RACGAP1 Proteins) activity of Dyn2 (show DNM2 Proteins)
Mutant p53 (show TP53 Proteins), which is known to support tumorigenesis via MVP (show MVP Proteins), promotes Arf6 activation.
The expression of miR (show MLXIP Proteins)-206 by HUVECs reduced exosome production by regulating ADP-Ribosylation Factor 6 (ARF6) and sodium/calcium exchanger 1 (NCX1 (show SLC8A1 Proteins)).
The role of EGFR (show EGFR Proteins)-ARF6 signaling in BA.
Data suggest ADAP2 (show ADAP2 Proteins) (an interferon-beta (show IFNB1 Proteins) stimulated gene) disrupts pathogenic internalization of some RNA viruses/virions (dengue, vesicular stomatitis) by altering ADP ribosylation factor 6-mediated processes including up-regulation of pinocytosis.
A dominant negative mutant of Arf6 blocks direct transport of APP (show APP Proteins) to lysosomes, but does not affect classical endocytosis to endosomes.
Results show that miR (show MLXIP Proteins)-145 directly targets the 3'UTR of ARF6 mRNA; its expression is upregulated in triple-negative breast cancer and tumor metastasis.
The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 guanine nucleotide exchange factor (show RASGRF1 Proteins) (GEF (show SLC2A4RG Proteins)) ARF nucleotide binding site opener (ARNO (show CYTH2 Proteins)) to bacterial entry sites.
Peripheral ARNO (show CYTH2 Proteins) promotes clathrin assembly through its GEF (show ARHGEF2 Proteins) activity for Arf6.
In platelet-specific Arf6 knockout mice,Arf6 KO platelets had less associated Fg suggesting that Arf6 affects alphaIIbbeta3-mediated Fg uptake and/or storage. They were also defective in FITC-Fg uptake and storage.
findings show for the first time that Ang II (show AGT Proteins) receptor signaling to beta-arrestin regulates ARF6 activation. These proteins together control receptor endocytosis and ultimately cell migration.
The role of ARF-6 and Annexin A2 (show ANXA2 Proteins) in the invasion of mammalian cells by T. cruzi amastigotes.
Findings demonstrate that Arf6 in neurons of the CNS plays an important role in oligodendrocyte precursor cells migration by regulating secretion of FGF-2 (show FGF2 Proteins) from neurons, thereby contributing to the axon myelination.
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Arf6 is required for hepatocyte growth factor (HGF (show HGF Proteins))-induced tumour neoangiogenesis and growth.
the activation-inactivation cycles of Rab35 (show RAB35 Proteins) and ARF6 are required for the uptake of zymosan and that ACAP2 (show ACAP2 Proteins) is an important component that links Rab35 (show RAB35 Proteins)/ARF6 signaling during phagocytosis of zymosan.
Arf6 plays an important role in oligodendrocyte precursor cells migration through regulation of FGF-2 (show FGF2 Proteins) secretion during neuronal development.
Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
PPAR (show PPARA Proteins) expression, the activity of its target gene AOX (show ACOX1 Proteins), and peroxisomal biogenesis are developmentally modulated in zebrafish
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP ribosylation factor III
, ADP-ribosylation factor 6
, peroxisome proliferator-activated receptor gamma