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Putative target protein of ADP-ribosylation factor. Additionally we are shipping ARFIP2 Antibodies (44) and ARFIP2 Kits (4) and many more products for this protein.
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Human ARFIP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098383
Joneson, McDonough, Bar-Sagi, Van Aelst: RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. in Science (New York, N.Y.) 1996
Show all 2 references for ABIN1098383
The data indicate that arfaptin 2 is the first molecule to regulate NF-kappaB (show NFKB1 Proteins) signaling by interacting with the functional IkappaB kinase (show CHUK Proteins) complex but not by direct inhibiting IKKbeta (show IKBKB Proteins) phosphorylation.
both Arf1 (show ARF1 Proteins) activation and high membrane curvature are required for efficient recruitment of Arfaptin2 to membranes
The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH.
The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association.
arfaptin 2 is involved in regulating huntingtin (show HTT Proteins) protein aggregation
arfaptin 2 phosphorylation at Ser260 by Akt (show AKT1 Proteins) inhibits PolyQ-huntingtin (show HTT Proteins)-induced toxicity by rescuing proteasome impairment
Highest level of Rac1 activation was achieved on the smallest nanofibers, a trend that was lost in POR1 knockdown. This supports the hypothesis that on small nanofibers, POR1 binds to highly curved cell membranes, allowing Rac1 to dissociate and activate.
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.
, ADP-ribosylation factor interacting protein 2
, ADP-ribosylation factor interacting protein 2 (arfaptin 2)
, partner of RAC1 (arfaptin 2)
, ADP-ribosylation factor-interacting protein 2
, Arfaptin 2
, partner of RAC1
, partner of Rac1