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anti-AF4/FMR2 Family, Member 4 (AFF4) Antibodies

The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia. Additionally we are shipping AFF4 Kits (4) and AFF4 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AFF4 27125 Q9UHB7
AFF4 93736 Q9ESC8
AFF4 303132  
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Top anti-AFF4 Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of AF5q31 Antibody (N-term) (ABIN653641) in HL-60 cell line lysates (35 µg/lane). AF5q31 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of AF5q31 Antibody (N-term) in HL-60 cell line lysates (35µg/lane). AF5q31 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of AFF4 expression in transfected 293T cell line by AFF4 monoclonal antibody (M01), clone 2E12. Lane 1: AFF4 transfected lysate( 40.2 KDa). Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to AFF4 on formalin-fixed paraffin-embedded human endometrium (antibody concentration 1 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Aff4 AntibodyTitration: 1.0 µg/mL  Positive Control: Rat Small Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Rat Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to AFF4 on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1 ug/ml] Western Blot analysis of AFF4 expression in transfected 293T cell line by AFF4 monoclonal antibody (M01), clone 2E12.Lane 1: AFF4 transfected lysate( 40.2 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$527.15
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.99 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated ELISA, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details

AFF4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-AFF4 Antibodies

  1. Human Polyclonal AFF4 Primary Antibody for EIA, WB - ABIN950293 : Lin, Smith, Takahashi, Lai, Martin-Brown, Florens, Washburn, Conaway, Conaway, Shilatifard: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. in Molecular cell 2010 (PubMed)
    Show all 6 references for ABIN950293

  2. Human Monoclonal AFF4 Primary Antibody for WB - ABIN394716 : He, Liu, Hsu, Xue, Chou, Burlingame, Krogan, Alber, Zhou: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. in Molecular cell 2010 (PubMed)
    Show all 5 references for ABIN394716

  3. Human Polyclonal AFF4 Primary Antibody for WB - ABIN653641 : Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007 (PubMed)
    Show all 3 references for ABIN653641

More Antibodies against AFF4 Interaction Partners

Human AF4/FMR2 Family, Member 4 (AFF4) interaction partners

  1. AFF4 is positioned to make unexpected direct contacts with HIV Tat (show TAT Antibodies), and Tat (show TAT Antibodies) enhances P-TEFb (show CCNT1 Antibodies)/CCNT1 (show CCNT1 Antibodies) affinity for AFF4.

  2. missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (show NIPBL Antibodies)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)

  3. HIV-1 Tat (show TAT Antibodies) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

  4. overexpression of AFF2 (show AFF2 Antibodies)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.

  5. Through the bridging functions of Tat (show TAT Antibodies) and AFF4, P-TEFb (show CCNT1 Antibodies) and ELL2 (show ELL2 Antibodies) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.

  6. AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.

  7. MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (show TAT Antibodies)-transactivation.

  8. Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]

Mouse (Murine) AF4/FMR2 Family, Member 4 (AFF4) interaction partners

  1. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (show MLLT1 Antibodies)/3 and AFF proteins that is critically important for MLL (show MLL Antibodies)-mediated transformation of HPCs

  2. AFF4 may therefore help to maintain activation of AMPK (show PRKAA1 Antibodies) downstream signaling under conditions of prolonged stimulation with ghrelin (show GHRL Antibodies), such as during fasting.

  3. AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.

  4. Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II

  5. In the absence of Runx1 (show RUNX1 Antibodies) on the silencer, P-TEFb (show CCNT1 Antibodies) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (show CD4 Antibodies) gene

AFF4 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).

Gene names and symbols associated with AFF4

  • AF4/FMR2 family, member 4 (aff4) antibody
  • AF4/FMR2 family, member 4 (AFF4) antibody
  • AF4/FMR2 family, member 4 (Aff4) antibody
  • AF5Q31 antibody
  • AFF4 antibody
  • Alf4 antibody
  • Laf4l antibody
  • MCEF antibody
  • RA_m002_jsmFBA6Br antibody

Protein level used designations for AFF4

AF4/FMR2 family, member 4 , ALL1 fused gene from 5q31 , AF4/FMR2 family member 4-like , AF4/FMR2 family member 4 , ALL1-fused gene from chromosome 5q31 protein , major CDK9 elongation factor-associated protein

GENE ID SPECIES
446225 Xenopus laevis
462058 Pan troglodytes
100137227 Papio anubis
100328920 Oryctolagus cuniculus
100403628 Callithrix jacchus
556421 Danio rerio
100548612 Meleagris gallopavo
27125 Homo sapiens
93736 Mus musculus
416337 Gallus gallus
474678 Canis lupus familiaris
541306 Bos taurus
303132 Rattus norvegicus
Selected quality suppliers for anti-AFF4 (AFF4) Antibodies
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