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The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia. Additionally we are shipping AFF4 Proteins (4) and many more products for this protein.
Showing 10 out of 68 products:
Human Polyclonal AFF4 Primary Antibody for EIA, WB - ABIN950293
Lin, Smith, Takahashi, Lai, Martin-Brown, Florens, Washburn, Conaway, Conaway, Shilatifard: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. in Molecular cell 2010
Show all 6 references for 950293
Human Monoclonal AFF4 Primary Antibody for WB - ABIN394716
He, Liu, Hsu, Xue, Chou, Burlingame, Krogan, Alber, Zhou: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. in Molecular cell 2010
Show all 5 references for 394716
Human Polyclonal AFF4 Primary Antibody for WB - ABIN653641
Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007
Show all 3 references for 653641
Human Polyclonal AFF4 Primary Antibody for ICC, IF - ABIN4278570
Stasevich, Hayashi-Takanaka, Sato, Maehara, Ohkawa, Sakata-Sogawa, Tokunaga, Nagase, Nozaki, McNally, Kimura: Regulation of RNA polymerase II activation by histone acetylation in single living cells. in Nature 2014
AFF4 is positioned to make unexpected direct contacts with HIV Tat (show TAT Antibodies), and Tat (show TAT Antibodies) enhances P-TEFb (show CCNT1 Antibodies)/CCNT1 (show CCNT1 Antibodies) affinity for AFF4.
missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (show NIPBL Antibodies)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)
HIV-1 Tat (show TAT Antibodies) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
overexpression of AFF2 (show AFF2 Antibodies)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.
Through the bridging functions of Tat (show TAT Antibodies) and AFF4, P-TEFb (show CCNT1 Antibodies) and ELL2 (show ELL2 Antibodies) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.
AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.
MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (show TAT Antibodies)-transactivation.
Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]
define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (show MLLT1 Antibodies)/3 and AFF proteins that is critically important for MLL (show MLL Antibodies)-mediated transformation of HPCs
AFF4 may therefore help to maintain activation of AMPK (show PRKAA1 Antibodies) downstream signaling under conditions of prolonged stimulation with ghrelin (show GHRL Antibodies), such as during fasting.
AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.
Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II
In the absence of Runx1 (show RUNX1 Antibodies) on the silencer, P-TEFb (show CCNT1 Antibodies) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (show CD4 Antibodies) gene
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).
AF4/FMR2 family, member 4
, ALL1 fused gene from 5q31
, AF4/FMR2 family member 4-like
, AF4/FMR2 family member 4
, ALL1-fused gene from chromosome 5q31 protein
, major CDK9 elongation factor-associated protein