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anti-AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) Antibodies

AFG3L2 encodes a protein localized in mitochondria and closely related to paraplegin. Additionally we are shipping AFG3L2 Kits (4) and AFG3L2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AFG3L2 10939 Q9Y4W6
AFG3L2 307350  
AFG3L2 69597 Q8JZQ2
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Top anti-AFG3L2 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-AFG3L2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB AFG3L2 Antibody (N-term)  western blot analysis in MDA-MB453,MCF-7,Jurkat cell line lysates (35ug/lane).This demonstrates the AFG3L2 antibody detected the AFG3L2 protein (arrow). AFG3L2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AFG3L2 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$529.83
Details
Human Rabbit Un-conjugated WB AFG3L2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

AFG3L2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Rat (Rattus)


Mouse (Murine)


Top referenced anti-AFG3L2 Antibodies

  1. Human Polyclonal AFG3L2 Primary Antibody for IHC (p), WB - ABIN657143 : Edener, Wöllner, Hehr, Kohl, Schilling, Kreuz, Bauer, Bernard, Gillessen-Kaesbach, Zühlke: Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 3 references for ABIN657143

  2. Chicken Polyclonal AFG3L2 Primary Antibody for WB - ABIN2782736 : Banfi, Bassi, Andolfi, Marchitiello, Zanotta, Ballabio, Casari, Franco: Identification and characterization of AFG3L2, a novel paraplegin-related gene. in Genomics 1999 (PubMed)

More Antibodies against AFG3L2 Interaction Partners

Human AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) interaction partners

  1. Deletion of AFG3L2 associated with spinocerebellar ataxia (show USP14 Antibodies) type 28 in the context of multiple genomic anomalies.

  2. AOA2 (show SETX Antibodies) with myoclonus associated with mutations in SETX (show SETX Antibodies) and AFG3L2

  3. This study that AFG3L2 mutations are another important cause, albeit rare, of a late-onset ataxic PEO (show POLG Antibodies) phenotype due to a disturbance of mtDNA maintenance.

  4. StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (show LONP1 Antibodies) protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin (show SPG7 Antibodies).

  5. Here, we report on a novel AFG3L2 mutation in a patient with slowly progressive ataxia (show USP14 Antibodies) and a positive family history.

  6. Identification of a partial AFG3L2 deletion and subsequent functional studies reveal loss of function as the most likely disease mechanism.

  7. Both full-length and truncated COX1 (show COX1 Antibodies) proteins physically interact with AFG3L2.

  8. These findings expand the phenotype associated with AFG3L2 mutations and suggest that AFG3L2-related disease should be considered in the differential diagnosis of spastic ataxias.

  9. The mutations of SCA28 are associated with amino acid changes in evolutionarily conserved residues of the alleged SCA28 gene, and indicate SCA28 as the sixth recognized SCA genotype caused by point mutations.

  10. We further confirm both the involvement of AFG3L2 gene in Spinocerebellar ataxia (show USP14 Antibodies) type 28 (SCA28) and the presence of a mutational hotspot in exons 15-16.

Mouse (Murine) AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) interaction partners

  1. AFG3L2 is critical to the surveillance mechanism that acts as a sensor to couple the synthesis of mitochondrial proteins with organelle fitness, thus ensuring coordinated assembly of the oxidative phosphorylation complexes from two sets of ribosomes.

  2. defective mitochondrial protein (show COX6B2 Antibodies) synthesis, leading to early-onset fragmentation of the mitochondrial network, is a central causative factor in AFG3L2-related neurodegeneration.

  3. These findings shed new light in the molecular mechanisms underlining neurodegeneration caused by AFG3L2 mutations.

  4. Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP.

  5. AFG3L2 mutant mouse models display a marked impairment of axonal development with delayed myelination and poor axonal growth.

  6. Spg7 (show SPG7 Antibodies) and Afg3l2 double mutants show an early-onset ataxic phenotype, indicating a role of the m-AAA (show AAAS Antibodies) proteases in cerebellar degeneration.

  7. demonstrate that cerebellum is the neuronal tissue with the highest susceptibility to reduced Afg3l2 dosage; propose that the Afg3l2 heterozygous mouse is an excellent model to unravel the pathological cascade leading to spinocerebellar ataxia (show USP14 Antibodies) type 28

AFG3L2 Antigen Profile

Protein Summary

This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

Gene names and symbols associated with AFG3L2

  • AFG3 ATPase family gene 3-like 2 (S. cerevisiae) (AFG3L2) antibody
  • AFG3 ATPase family gene 3-like 2 (S. cerevisiae) (afg3l2) antibody
  • AFG3 ATPase family member 3-like 2 (S. cerevisiae) (afg3l2) antibody
  • AFG3 ATPase family member 3-like 2 (S. cerevisiae) (AFG3L2) antibody
  • AFG3 ATPase family member 3-like 2 (S. cerevisiae) (Afg3l2) antibody
  • AFG3(ATPase family gene 3)-like 2 (yeast) (Afg3l2) antibody
  • 2310036I02Rik antibody
  • AW260507 antibody
  • Emv66 antibody
  • MGC147390 antibody
  • par antibody
  • SCA28 antibody
  • si:ch211-12e1.4 antibody
  • SPAX5 antibody

Protein level used designations for AFG3L2

AFG3 ATPase family gene 3-like 2 (S. cerevisiae) , AFG3 ATPase family gene 3-like 2 , AFG3 ATPase family gene 3-like 2-like , AFG3-like protein 2-like , AFG3-like protein 2 , AFG3-like protein 2 (Paraplegin-like protein) , ATPase family gene 3, yeast , paraplegin-like protein

GENE ID SPECIES
455507 Pan troglodytes
578526 Strongylocentrotus purpuratus
703079 Macaca mulatta
780216 Xenopus (Silurana) tropicalis
100018022 Monodelphis domestica
100367333 Saccoglossus kowalevskii
100410379 Callithrix jacchus
100448741 Pongo abelii
100484304 Ailuropoda melanoleuca
569168 Danio rerio
421036 Gallus gallus
490560 Canis lupus familiaris
515757 Bos taurus
443667 Xenopus laevis
10939 Homo sapiens
307350 Rattus norvegicus
69597 Mus musculus
Selected quality suppliers for anti-AFG3L2 (AFG3L2) Antibodies
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