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The mouse homolog of AKTIP produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. Additionally we are shipping AKTIP Proteins (11) and AKTIP Kits (8) and many more products for this protein.
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Human Polyclonal AKTIP Primary Antibody for WB - ABIN1881052
Quaye, Dafou, Ramus, Song, Gentry-Maharaj, Maharaj, Notaridou, Hogdall, Kjaer, Christensen, Hogdall, Easton, Jacobs, Menon, Pharoah, Gayther: Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. in Human molecular genetics 2009
Show all 3 references for ABIN1881052
Chicken Polyclonal AKTIP Primary Antibody for WB - ABIN2786570
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007
AKTIP interacts with telomeric DNA and is required for telomere maintenance.
High fused toes homolog expression is associated with radioresistance in cervical cancer.
FTS silencing reduced EMT (show ITK Antibodies) and cell migration by EGF (show EGF Antibodies) treatment. These results demonstrate a novel function for FTS in EGF (show EGF Antibodies)-mediated EMT (show ITK Antibodies) process.
*AKTIP single nucleotide polymorphisms are not associated with late-onset depression patients compared to healthy elderly controls.
Targeted inhibition of FTS led to the shutdown of key elemental characteristics of cervical cancer and could lead to an effective therapeutic strategy.
These data unraveled the involvement of new oncoprotein FTS in cervical cancer which plays a central role in carcinogenesis.
Demographic and clinical characteristics and AKT1 (show AKT1 Antibodies) single markers and haplotypes, but not AKTIP polymorphisms or interactions between AKT1 (show AKT1 Antibodies) and AKTIP, are associated with increased risk for suicidal behavior in bipolar patients.
Ft1 protein interacts directly with PKB (show AKT1 Antibodies), enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1 (show PDK1 Antibodies)
These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex.
Ft1 protein is required for telomere maintenance.
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
AKT interacting protein
, fused toes homolog
, AKT-interacting protein
, Fused toes protein homolog
, fused toes protein homolog
, AKT-interacting protein homolog B
, fused toes protein