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ALX3 encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Additionally we are shipping ALX3 Proteins (4) and ALX3 Kits (1) and many more products for this protein.
Showing 10 out of 29 products:
Cow (Bovine) Polyclonal ALX3 Primary Antibody for WB - ABIN2780288
Yamada, Mizutani-Koseki, Koseki, Takahashi: Requirement for Mab21l2 during development of murine retina and ventral body wall. in Developmental biology 2004
Exclusion of mutations in ALX3 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies
We report a novel Y214X mutation in ALX3 in frontorhiny.
The lack of a chromosome 1-derived fragment of ALX3 in restriction landmark genomic scanning and virtual genome scans of neuroblastomas is attributable to hypermethylation.
Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin (show INS Antibodies) genes.
ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny.
Rat Alx3 undergoes restrictive or permissive interactions with nuclear proteins that determine its binding to and transactivation from TAAT target sites selected in a cell-specific manner.
Glucose-stimulated expression of ALX3 in alpha cells provides a regulatory mechanism for the downregulation of glucagon (show GCG Antibodies) gene expression by interfering with PAX6 (show PAX6 Antibodies)-mediated transactivation on the glucagon (show GCG Antibodies) G1 promoter element.
Pdx1 (show PDX1 Antibodies), USF1 (show USF1 Antibodies) and USF2 (show USF2 Antibodies) co-ordinately regulate Alx3 gene expression in pancreatic beta-cells.
Alx3 promoter activity in mesenchymal and pancreatic cells is regulatd by USF transcription factors and Twist1 (show TWIST1 Antibodies)
ALX3 could be considered as a candidate gene for the etiopathogenesis of diabetes or its complications during embryonic or fetal development is discussed
ALX3 participates in the regulation of the expression of essential genes for the function of pancreatic islets, and its deficiency alters the regulation of glucose homeostasis in vivo.
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors.
ALX homeobox 3
, aristaless-like homeobox 3
, homeobox protein aristaless-like 3
, proline-rich transcription factor ALX3
, aristaless 3
, proline-rich transcription factor Alx3