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anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Antibodies

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Additionally we are shipping APEX2 Proteins (3) and APEX2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 289662  
APEX2 77622 Q68G58
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Top anti-APEX2 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of APEX2 Antibody (Center) (ABIN652924) in MCF-7... Formalin-fixed and paraffin-embedded human lung carcinoma reacted with... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- APEX2 antibody, Western blotting All lanes: Anti APEX2  at 0.5ug... Anti- APEX2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Un-conjugated WB APEXL2 pAb tested by Western blot. APEXL2 detection by Western blot. T... 200 μL Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details

APEX2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Rat (Rattus) , ,

Mouse (Murine) , ,

Top referenced anti-APEX2 Antibodies

  1. Human Polyclonal APEX2 Primary Antibody for FACS, IF - ABIN652924 : Hadi, Ginalski, Nguyen, Wilson: Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. in Journal of molecular biology 2002 (PubMed)

More Antibodies against APEX2 Interaction Partners

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (show CHEK1 Antibodies); a serine residue (S86) in the Chk1 (show CHEK1 Antibodies)-binding motif of APE2 is essential for Chk1 (show CHEK1 Antibodies) phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 in ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease (show DCLRE1C Antibodies) specificity of Ape1 (show APEX1 Antibodies) and Ape2, human homologues of Escherichia coli exonuclease (show EXO1 Antibodies) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (show PCNA Antibodies)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (show RPLP0 Antibodies)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (show AICDA Antibodies) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (show APEX1 Antibodies) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (show AKAP17A Antibodies) transition, due to a p53 (show TP53 Antibodies)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (show APEX1 Antibodies).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (show APEX1 Antibodies) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Antigen Profile

Protein Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1) antibody
  • apurinic/apyrimidinic endonuclease 2 (Apex2) antibody
  • APE2 antibody
  • APEXL2 antibody
  • C430040P13Rik antibody
  • XTH2 antibody
  • zgc:55889 antibody

Protein level used designations for APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPECIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
Selected quality suppliers for anti-APEX2 (APEX2) Antibodies
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