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APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 Proteins (APEX2)

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Additionally we are shipping APEX2 Antibodies (51) and APEX2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APEX2 27301 Q9UBZ4
Rat APEX2 APEX2 289662  
APEX2 77622 Q68G58
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Top APEX2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

APEX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaction Partners

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (show CHEK1 Proteins); a serine residue (S86) in the Chk1 (show CHEK1 Proteins)-binding motif of APE2 is essential for Chk1 (show CHEK1 Proteins) phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 (show CHEK1 Proteins) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease (show DCLRE1C Proteins) specificity of Ape1 (show APEX1 Proteins) and Ape2, human homologues of Escherichia coli exonuclease (show EXO1 Proteins) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (show PCNA Proteins)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (show RPLP0 Proteins)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (show AICDA Proteins) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (show APEX1 Proteins) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (show AKAP17A Proteins) transition, due to a p53 (show TP53 Proteins)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (show APEX1 Proteins).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (show APEX1 Proteins) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Protein Profile

Protein Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2)
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2)
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1)
  • apurinic/apyrimidinic endonuclease 2 (Apex2)
  • APE2 protein
  • APEXL2 protein
  • C430040P13Rik protein
  • XTH2 protein
  • zgc:55889 protein

Protein level used designations for APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPECIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
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