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ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180\; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]..
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Human Polyclonal ARID2 Primary Antibody for IHC - ABIN965591
Patsialou, Wilsker, Moran: DNA-binding properties of ARID family proteins. in Nucleic acids research 2005
Show all 4 references for ABIN965591
This is the first report of mutations in ARID2 associated with developmental delay and intellectual disabilities .
Arid2 role in genome-wide transcriptional regulation by SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complexes.
The subsequent validation study on 68 LCBs identified recurrent mutations in TERT promoter, chromatin regulators (BAP1, PBRM1 and ARID2), a synapse organization gene (PCLO), IDH genes and KRAS.
loss of ARID2 protein expression may be associated with recurrence of hepatocellular carcinoma
Mutations in ARID2 gene is associated with microsatellite unstable colorectal cancer.
Recurrent inactivating mutations of ARID2 is associated with non-small cell lung carcinoma.
we summarize the current knowledge about the relevance of ARID2 in Hepatocellular carcinoma and the implication in future patient care
18.2% of individuals with HCV-associated HCC (show FAM126A Antibodies) in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.
zipzap may serve as a transcription co-activator for the regulation of cardiac gene expression
a critical role for ARID2-containing complexes in promoting osteoblast differentiation and supports a view that the PBAF subset of SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) contributes importantly to maintaining cellular identity and activating tissue-specific gene expression.
ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180\; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005
AT rich interactive domain 2 (ARID, RFX-like)
, AT-rich interactive domain-containing protein 2
, AT-rich interactive domain-containing protein 2-like
, ARID domain-containing protein 2
, BRG1-associated factor 200
, zinc finger protein with activation potential
, AT rich interactive domain 2 (Arid-rfx like)