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The protein encoded by ATG16L1 is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Additionally we are shipping ATG16L1 Kits (8) and ATG16L1 Proteins (6) and many more products for this protein.
Showing 10 out of 167 products:
Human Polyclonal ATG16L1 Primary Antibody for IF, IHC (p) - ABIN388542
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IHC (p) - ABIN1449612
Nomura, Uzawa, Yamano, Fushimi, Ishigami, Kouzu, Koike, Siiba, Bukawa, Yokoe, Kubosawa, Tanzawa: Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis. in Human pathology 2008
Show all 8 references for ABIN1449612
Human Polyclonal ATG16L1 Primary Antibody for IHC (p), WB - ABIN388543
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IHC (p) - ABIN1449636
Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. in The Journal of biological chemistry 2010
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IF - ABIN497988
Kamada, Funakoshi, Shintani, Nagano, Ohsumi, Ohsumi: Tor-mediated induction of autophagy via an Apg1 protein kinase complex. in The Journal of cell biology 2000
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Human Polyclonal ATG16L1 Primary Antibody for IF, IHC (p) - ABIN388541
Greenberg: Degrade or die: a dual function for autophagy in the plant immune response. in Developmental cell 2005
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IF - ABIN499355
Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004
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Human Polyclonal ATG16L1 Primary Antibody for DB - ABIN389754
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Dog (Canine) Polyclonal ATG16L1 Primary Antibody for EIA, WB - ABIN783914
Rioux, Xavier, Taylor, Silverberg, Goyette, Huett, Green, Kuballa, Barmada, Datta, Shugart, Griffiths, Targan, Ippoliti, Bernard, Mei, Nicolae, Regueiro, Schumm, Steinhart, Rotter, Duerr, Cho, Daly et al.: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ... in Nature genetics 2007
Subjects homozygous for the autophagy-related 16-like protein (ATG16L1) CD-associated gene variant (rs2241880), had low SHIP mRNA expression and activity.
The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon (show IFNA Antibodies).
ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12 (show ATG12 Antibodies)-ATG5 (show ATG5 Antibodies)-ATG16L1 complex and autophagy induction
Knockdown of Atg16L1, a crucial autophagy gene, leads to developmental retention of early-stage cells in various tissues where the differentiation of stem cells is retarded.
Antibacterial autophagy is impaired in CLEC12A (show CLEC12A Antibodies)-deficient cells, and this effect is exacerbated in the presence of the ATG16L1( *)300A risk allele.
ATG16L1 may be used as a biomarker for selecting oral squamous cell carcinoma patients with a more aggressive phenotype.
CNTNAP3 (show CNTNAP3 Antibodies) could upregulate the expression of ATG16L1 and increase autophagy vacuoles
ATG16L1 variant rs2241880 was associated with 38% increase in the risk for Crohn's disease for higher mutational load, whereas IL23R (show IL23R Antibodies) variant rs11209026 decreased the risk by 54% for higher mutational load.
CD patients homozygous for the ATG16L1-T300A risk allele show impaired clearance of pathosymbionts in ileal inflammation indicating that ATG16L1 is essential for effective elimination of pathosymbionts upon inflammation.
genotyped 31 Crohn's disease (CD)-associated genes in 102 Slovenian patients. The strongest association for treatment response defined as decrease in CRP (show CRP Antibodies) levels was found for ATG16L1 SNP rs10210302.
Arg-24 of Atg16L1 is crucial for its interaction with Atg5 (show ATG5 Antibodies) which has implications in the binding of the dimeric complex to Rab33B (show RAB33B Antibodies)
inhibition of IL-1beta (show IL1B Antibodies) signaling abrogates the ATG16L1-dependent protection from Urinary tract infections
A hypomorphic mutation in Atg16L1, a crucial autophagy gene, leads to developmental retention of early-stage cells in various tissues where the differentiation of stem cells is retarded.
findings suggest that the regulatory axis of HIF-1alpha (show HIF1A Antibodies)-miRNA-20a-Atg16l1 might be a critical mechanism for hypoxia-induced osteoclast differentiation
Atg16L1 deficiency leads to an exacerbated graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation.
nucleotide-binding oligomerization domain containing 2 (show NOD2 Antibodies) deficiency did not reverse the ATG16L1-deficiency-induced protection from urinary tract infections
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Data indicate that human ATG16L1 and mouse autophagy components Atg7 (show ATG7 Antibodies) and Atg16L1 participate in the IFN-gamma-induced (show SAMHD1 Antibodies) recruitment of the immunity-related GTPases to the intracellular pathogen.
An Atg16L1 deficiency alters the intestinal environment to mediate an enhanced immune response that is dependent on monocytic cells.
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.
ATG16 autophagy related 16-like 1 (S. cerevisiae)
, APG16 autophagy 16-like
, autophagy-related protein 16
, APG16-like 1
, autophagy-related 16-like
, ATG16 autophagy related 16-like 1
, autophagy-related protein 16-1-like
, autophagy-related protein 16-1
, APG16L beta
, WD repeat domain 30
, Atg16L1 gamma
, autophagy-related 16-like 1 gamma
, autophagy-related 16-like 1