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ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) Proteins (ATG4B)

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Additionally we are shipping ATG4B Antibodies (143) and ATG4B Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATG4B 23192 Q9Y4P1
ATG4B 66615 Q8BGE6
Rat ATG4B ATG4B 316640  
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Top ATG4B Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$3,345.83
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Yeast Rice His tag   1 mg Log in to see 56 to 66 Days
$3,349.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$534.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ATG4B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced ATG4B Proteins

  1. Human ATG4B Protein expressed in Escherichia coli (E. coli) - ABIN668029 : Kumanomidou, Mizushima, Komatsu, Suzuki, Tanida, Sou, Ueno, Kominami, Tanaka, Yamane: The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. in Journal of molecular biology 2005 (PubMed)
    Show all 2 references for ABIN668029

More Proteins for ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) Interaction Partners

Arabidopsis thaliana ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) interaction partners

  1. These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.

  2. AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]

Xenopus laevis ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) interaction partners

Human ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) interaction partners

  1. Results demonstrated that upregulation of miR (show MLXIP Proteins)-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR (show MLXIP Proteins)-34a through AMPK (show PRKAA1 Proteins)/mTOR (show FRAP1 Proteins), was involved in this process.

  2. Purified ATG4B protein interact with LC3B (show MAP1LC3B Proteins) in vitro.

  3. ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells.

  4. This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia (show BCL11A Proteins) stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells.

  5. The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts.

  6. Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A (show ATG4A Proteins) for ATG8 (show GABARAPL2 Proteins) substrates

  7. HsAtg4B negatively regulates the localization of LC3 (show MAP1LC3A Proteins) to a membrane compartment by delipidation

  8. crystal structure of human Atg4b by X-ray crystallography at 2.0 A resolution, and show that Atg4b is a cysteine protease (show CTSB Proteins) whose active catalytic triad site consists of Cys74, His280 and Asp278

  9. Murine Atg8L/Apg8L (show GABARAPL1 Proteins) modification is mediated by human Atg4B.

  10. The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 (show MAP1LC3A Proteins) showed that, on LC3 (show MAP1LC3A Proteins) binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes.

Mouse (Murine) ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) interaction partners

  1. miR (show MLXIP Proteins)-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs.

  2. the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis

  3. REDD1 (show DDIT4 Proteins)/TXNIP (show TXNIP Proteins) complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy.

  4. these findings demonstrate a role for Ser (show SIGLEC1 Proteins)-383 and Ser (show SIGLEC1 Proteins)-392 phosphorylation of ATG4B in control of autophagy.

  5. mTOR (show FRAP1 Proteins) inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux.

  6. An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA (show CEBPB Proteins) and is shown to play an important role in 3T3-L1 adipocyte differentiation.

  7. the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 (show MAP1LC3A Proteins) processing and autophagy.

  8. The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.

  9. Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod.

  10. The Apg4B/autophagin-1 protease thus serves as a processing/deconjugating enzyme for these four highly divergent mammalian Apg8 homologues, GATE-16 (show GABARAPL2 Proteins), MAP1 (show MOAP1 Proteins)-LC3 (show MAP1LC3A Proteins), GABARAP (show GABARAP Proteins), and Apg8L (show GABARAPL1 Proteins).

ATG4B Protein Profile

Protein Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with ATG4B

  • autophagy related 4B, cysteine peptidase (ATG4B)
  • autophagy-related 4b (Atg4b)
  • cysteine protease ATG4b (AT3G59950)
  • cysteine protease ATG4B (Tsp_08582)
  • cysteine protease ATG4B (Tsp_11599)
  • ATG4 autophagy related 4 homolog B (S. cerevisiae) (atg4b)
  • ATG4 autophagy related 4 homolog B (S. cerevisiae) (ATG4B)
  • autophagy related 4B, cysteine peptidase (atg4b)
  • autophagy related 4B, cysteine peptidase (Atg4b)
  • 2510009N07Rik protein
  • Apg4b protein
  • Atg4bl protein
  • Aut2b2 protein
  • Autl1 protein
  • AW048066 protein

Protein level used designations for ATG4B

ATG4 autophagy related 4 homolog B , cysteine protease ATG4B , autophagy 4b variant 1Cysteine protease ATG4B , autophagy 4b variant 3 , cysteine protease ATG4b , APG4 autophagy 4 homolog B , autophagy-related protein 4 homolog B , AUT2B , autophagin-2B , autophagy-related cysteine endopeptidase 2B , cAut2B , AUT-like 1 cysteine endopeptidase , autophagin-1 , autophagy-related cysteine endopeptidase 1 , hAPG4B , APG4 (ATG4) autophagy-related homolog B , AUT-like 1, cysteine endopeptidase , autophagin 1 , autophagy-related 4B , cysteine protease involved in autophagy APG4-B , autophagy related 4 homolog B , autophagy related 4-like protein B , bAut2B

GENE ID SPECIES
748674 Pan troglodytes
100067797 Equus caballus
100240691 Zea mays
825165 Arabidopsis thaliana
10907016 Trichinella spiralis
10912977 Trichinella spiralis
100194746 Salmo salar
448859 Danio rerio
404750 Gallus gallus
494717 Xenopus laevis
23192 Homo sapiens
66615 Mus musculus
316640 Rattus norvegicus
609599 Canis lupus familiaris
100462747 Sus scrofa
408002 Bos taurus
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