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Required for autophagy. Additionally we are shipping ATG5 Antibodies (255) and ATG5 Kits (11) and many more products for this protein.
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Human ATG5 Protein expressed in Escherichia coli (E. coli) - ABIN667343
Mizushima, Noda, Yoshimori, Tanaka, Ishii, George, Klionsky, Ohsumi, Ohsumi: A protein conjugation system essential for autophagy. in Nature 1998
Show all 2 references for ABIN667343
The important role of atg5 gene in zebrafish neurogenesis and organogenesis, is reported.
ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants.
study established a relationship between trans-eSNPs of ATG5 and lupus nephritis in a northern Han population from China
in the presence of 3-MA and Atg5 siRNA, autophagy was inhibited, LC3 (show MAP1LC3A Proteins)-II expression decreased and cell apoptosis increased
This study demonstrated an association of ATG5 rs573775 with BD and ATG10 rs4703863 with VKH syndrome in a Chinese Han population.
KIM-1-/TIM-1 (show HAVCR1 Proteins)-mediated phagocytosis links ATG5-/ULK1 (show ULK1 Proteins)-dependent clearance of apoptotic cells to antigen presentation.
Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.
provide an insight into a model for swapping ATG5 partners for autophagosome maturation
the crystal structures of human ATG5 in complex with an N-terminal domain of ATG16L1 as well as an internal AIR domain of TECPR1, are reported.
Taken together, the results demonstrate that ATG5 cleavage provokes apoptosis and represents a molecular link between autophagy and apoptosis
Increased frequencies of rare variants of ATG5 were identified in patients with LN and Systemic Lupus Erythematosus compared with healthy controls, highlighting a likely important role of rare ATG5 variants in Chinese SLE patients.
Increased expression of ATG5 was significantly correlated with poor overall survival and chemoresistance in gastric cancer.
Arg-24 of Atg16L1 (show ATG16L1 Proteins) is crucial for its interaction with Atg5 which has implications in the binding of the dimeric complex to Rab33B (show RAB33B Proteins)
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Treg cell-specific deletion of Atg5 leads to loss of Treg cells, greater tumor resistance and development of inflammatory disorders.
The results in a potent increase in odontoblastic cell differentiation, indicating the unique involvement of Atg5, autophagy and Wnt5 (show WNT5A Proteins) signaling in CS/BMP-4 (show BMP4 Proteins)-induced differentiation of ES cells into odontoblast-like cells, at a relatively early stage.
Deletion of Atg5 in chondrocytes promoted age-related osteoarthritis, but no difference in the development of post-traumatic osteoarthritis.
the unique involvement of Atg5 in IL-1beta (show IL1B Proteins)-induced proliferation of embryonic stem cell-derived odontoblast-like cells
Data show that the autophagy-related 5 protein (Atg5)-independent autophagy is crucial for establishing pluripotency.
ATG5 plays a unique role in protection against M. tuberculosis by preventing PMN-mediated immunopathology; and while Atg5 is dispensable in alveolar macrophages during M. tuberculosis infection, loss of Atg5 in PMNs can sensitize mice to M. tuberculosis
Our results demonstrate that ATG5 plays important roles in intestinal tumor growth and combination of IFN-g and ATG5 deficiency or ATG5-targeted inhibition is a promising strategy for prevention and treatment of colorectal cancer .
in KRas(G12D)-driven lung cancer, Atg5-regulated autophagy accelerates tumour progression; however, autophagy also represses early oncogenesis, suggesting a link between deregulated autophagy and regulatory T cell controlled anticancer immunity.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5, mTOR (show FRAP1 Proteins), Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).
, ATG5 autophagy related 5 homolog
, APG5 autophagy 5-like
, autophagy 5-like protein
, autophagy protein 5
, apoptosis specific protein
, apoptosis-specific protein
, autophagy-related 5
, potential preautophagosome nucleating protein Atg5