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anti-ATP Citrate Lyase (ACLY) Antibodies

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Additionally we are shipping ACLY Kits (13) and ACLY Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
ACLY 24159 P16638
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Top anti-ACLY Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ACLY Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: ACHN cell lysate WB Suggested Anti-ACLY  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: ACHN cell lysate  ACLY is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using ACLY mouse mAb (green) and negative control (purple) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated ICC, FACS, WB ACLY (C-terminus) antibody at 1/1000 dilution, Lane1: K562 whole cell lysate 40ug/lane, Lane2: Jurkat whole cell lysate 40ug/lane, Lane3: Hela whole cell lysate 40ug/lane, Predicted band size: 120kDa, Observed band size: 120kDa ACLY (C-terminus) antibody at 1/2000 dilution+K562 whole cell lysate 40ug/lane, Predicted band size: 120kDa, Observed band size: 120kDa. 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, IHC (p), WB Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) 100 μL Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COS7 cells, treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Ab-454) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ICC, FACS, IF, IHC, ELISA, WB 100 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-ACLY mouse monoclonal antibody. (ABIN2452694, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-ACLY mouse monoclonal antibody. (ABIN2452694, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated IF, WB Western blot analysis of ATP-citrate synthase antibody in extracts from COS7 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

ACLY Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ACLY Antibodies

  1. Human Monoclonal ACLY Primary Antibody for ICC, FACS - ABIN1098143 : Chu, Lin, Hendel, Kulpa, Brownsey, Johnson: ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN1098143

  2. Human Polyclonal ACLY Primary Antibody for WB - ABIN2775558 : Infantino, Iacobazzi, Palmieri, Menga: ATP-citrate lyase is essential for macrophage inflammatory response. in Biochemical and biophysical research communications 2013 (PubMed)

More Antibodies against ACLY Interaction Partners

Human ATP Citrate Lyase (ACLY) interaction partners

  1. ACC1 (show ACACA Antibodies) and ACLY regulate the levels of ETV4 (show ETV4 Antibodies) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (show ACACA Antibodies)/ACLY-alpha-ketoglutarate-ETV4 (show ETV4 Antibodies) axis is a novel means by which metabolic states regulate transcriptional output

  2. ACL activity is associated with increased ATP. Activation of this IGF1 (show IGF1 Antibodies)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  3. These results suggest that the combined expression of GLUT1 (show SLC2A1 Antibodies) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  4. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

  5. SNP rs9912300 in ACLY gene was significantly associated with response to therapy in hepatocellular carcinoma

  6. The activation of AMPK (show PRKAA1 Antibodies) under ACLY knockdown conditions may lead to p53 (show TP53 Antibodies) activation, ultimately leading to cellular senescence.

  7. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.

  8. These data indicate that inhibition of ACLY might affect both fatty acid elongation in ER and FAO in mitochondria, thereby explaining the TG accumulation with altered fatty acid composition.

  9. ACLY inhibition exerts an anticancer effect via increased reactive oxygen species, and p-AMPK (show PRKAA1 Antibodies) could be a predictive biomarker for its therapeutic outcome.

  10. Single nucleotide polymorphisms in the ACACA (show ACACA Antibodies) and ACLY genes are associated with a relative change in plasma triglycierides following fish oil supplementation.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (show TLR4 Antibodies) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  2. Results suggest a role for DNA methyltransferase 1 (DNMT1 (show DNMT1 Antibodies)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (show MLXIP Antibodies)-148a-dependent mechanism for regulating DNMT1 (show DNMT1 Antibodies) during adipogenesis.

  3. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (show PC Antibodies), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  4. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (show APOC4 Antibodies) in lipid metabolism.

  5. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  6. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  7. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (show TFAP2A Antibodies).

ACLY Antigen Profile

Protein Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ACLY

  • ATP citrate lyase (ACLY) antibody
  • ATP citrate lyase (acly) antibody
  • ATP citrate lyase (ATPCL) antibody
  • ATP-citrate synthase (AaeL_AAEL004297) antibody
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) antibody
  • ATP-citrate synthase (Bm1_26245) antibody
  • atp-citrate synthase (ACL) antibody
  • ATP citrate lyase (Acly) antibody
  • ATP citrate lyase a (aclya) antibody
  • A730098H14Rik antibody
  • ACL antibody
  • acly antibody
  • anon-WO0140519.179 antibody
  • ATPCL antibody
  • AW538652 antibody
  • BcDNA:LD21334 antibody
  • cb722 antibody
  • CG8322 antibody
  • Clatp antibody
  • dATPCL antibody
  • DDBDRAFT_0205389 antibody
  • DDBDRAFT_0235360 antibody
  • DDB_0205389 antibody
  • DDB_0235360 antibody
  • DmATPCL antibody
  • Dmel\\CG8322 antibody
  • l(2)01466 antibody
  • l(2)k09217 antibody
  • n(2)k09217 antibody
  • zgc:92008 antibody

Protein level used designations for ACLY

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

GENE ID SPECIES
100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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