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The membrane-associated protein encoded by ABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA1 Kits (35) and ABCA1 Proteins (8) and many more products for this protein.
Showing 10 out of 179 products:
Chicken Polyclonal ABCA1 Primary Antibody for ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. in Journal of lipid research 2004
Show all 243 references for ABIN152883
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. in The Journal of biological chemistry 2002
Show all 13 references for ABIN268847
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. in PLoS ONE 2009
Show all 6 references for ABIN268899
Human Monoclonal ABCA1 Primary Antibody for CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. in American journal of physiology. Renal physiology 2009
Show all 5 references for ABIN4277133
Human Polyclonal ABCA1 Primary Antibody for FACS, IF (p) - ABIN732188
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN2781512
Fu, Mukhamedova, Ip, DSouza, Henley, DiTommaso, Kesani, Ditiatkovski, Jones, Lane, Jennings, Smyth, Kile, Sviridov: ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. in Cell metabolism 2013
our results highlight the importance of the LXR (show NR1H3 Antibodies)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Antibodies) or ABCG1 (show ABCG1 Antibodies) but not ABCA1.
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
ApoA-I (show APOA1 Antibodies) induces S1P (show MBTPS1 Antibodies) release from endothelial cells through ABCA1 and SR-BI (show SCARB1 Antibodies) in a positive feedback manner.
Results suggest that enhanced expression of miR (show MLXIP Antibodies)-33a might induce cholesterol accumulation and aggravate inflammation in vessel walls by suppressing the expression of ABCA1 in macrophages.
AIBP (show APOA1BP Antibodies) promotes apoA-1 (show APOA1 Antibodies) binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2 (show CSN2 Antibodies)-mediated degradation so as to prevent foam cell formation
ABCA1 gene expression positively correlated with obesity indicators.
The results of this study indicated that ABCA1 rs2422493 polymorphism was statistically significant associated with increasing Alzheimer's disease risk.
These findings suggest that some common variants on the chromosome 9p21 and ABCA1 and their interactions may significantly modify the risk of Coronary Heart Disease and is independent of effects on serum lipid levels.
In people with mild cognitive impairement and Alzheimer disease, the capacity of CSF (show CSF2 Antibodies) to facilitate ABCA1-mediated cholesterol efflux is impaired.
miR (show MLXIP Antibodies)-183 degrades ABCA1 mRNA in colon cancer cells.
Absence of ABCA1 and low HDL (show HSD11B1 Antibodies) level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 (show TBXA2R Antibodies) production through a hematopoietic ABCA1-independent mechanism.
rs708272 polymorphism showed protective effect (B1 vs. B2: OR = 0.80, P = 0.003 and B2B2 vs. B1B1: OR = 0.68, P = 0.012) while the ABCA1 variant rs2066715 was not associated
The ABCA1 may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs (show TWIST1 Antibodies) in response to testicular injury.
Both depletion of PARP-1 (show PARP1 Antibodies) and inhibition of PARP-1 (show PARP1 Antibodies) activity augmented LXR (show NR1H3 Antibodies) ligand-induced ABCA1 expression in the RAW 264.7 macrophage line and primary bone marrow-derived macrophages but did not affect LXR (show NR1H3 Antibodies)-dependent expression of other target genes, ABCG1 (show ABCG1 Antibodies) and SREBP-1c (show SREBF1 Antibodies).
Visfatin (show NAMPT Antibodies) upregulated CD36 (show CD36 Antibodies) and SRA (show MSR1 Antibodies) expression and downregulated ABCA1 and ABCG1 (show ABCG1 Antibodies) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (show EPHB2 Antibodies)-dependent pathways.
These studies point to an important role for hematopoietic ABCA1 in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes.
These findings may be clinically relevant because HDL's APOE (show APOE Antibodies) content associates with CVD risk and ABCA1 deficiency promotes unregulated cholesterol accumulation in human macrophages.
Short-term modulation of miR (show MLXIP Antibodies)-27b expression in wild-type mice regulates hepatic LDLR (show LDLR Antibodies) and ABCA1 expression but does not influence plasma and hepatic lipid levels.
LXR (show NR1H3 Antibodies) activation reduces the growth of xenograft tumour of human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 expression and the decline of cholesterol levels in the tumour.
PGG enhances expression of SR-BI (show SCARB1 Antibodies) and ABCA1 in J774 and THP-1 (show GLI2 Antibodies) macrophages
ABCA1(-/-) macrophages deposited much less extracellular cholesterol than wild-type macrophages. These findings demonstrate a novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix.
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Antibodies) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette 1