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The membrane-associated protein encoded by ABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA1 Kits (42) and ABCA1 Proteins (8) and many more products for this protein.
Showing 10 out of 145 products:
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN2781512
Fu, Mukhamedova, Ip, DSouza, Henley, DiTommaso, Kesani, Ditiatkovski, Jones, Lane, Jennings, Smyth, Kile, Sviridov: ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. in Cell metabolism 2013
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for FACS - ABIN2477222
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. in Pflügers Archiv : European journal of physiology 2007
our results highlight the importance of the LXR (show NR1H3 Antibodies)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Antibodies) or ABCG1 (show ABCG1 Antibodies) but not ABCA1.
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
These results indicate that simian immunodeficiency virus infection is a significant contributor to primary dyslipidemia, likely through the ability of Nef to suppress ABCA1-dependent reverse cholesterol transport.
This work shows that substantial amounts of precursor sterols are transported to a certain PM domain and are removed by the ABCA1-dependent pathway.
Our results suggest that ABCA1 polymorphisms influence plasma lipid variability and coronary heart disease risk
this study aimed to investigate the relationship between ABCA1 polymorphism and apoA-I (show APOA1 Antibodies) and HDL (show HSD11B1 Antibodies)-C in an attempt to elucidate its correlation with abdominal aortic aneurysm occurrence.
Quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPARgamma (show PPARG Antibodies) and ABCA1.
miR (show MLXIP Antibodies)-28-5p participates in atherosclerosis via ERK2 (show MAPK1 Antibodies)-mediated upregulation of the ABCA1 pathway.
ABCA1 gene polymorphisms may be associated with low HDL (show HSD11B1 Antibodies)-C disease; the low HDL (show HSD11B1 Antibodies)-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity.
The present meta-analysis indicated that the T allelic in rs1883025 variant was significantly associated with the risk of developing AMD (show AMD1 Antibodies), particularly at the early stage.
The present study shows that there is no significant difference in the genotypic and allelic frequencies of ABCA1 rs2230806, rs3890182 and rs1800976 polymorphisms between a normal weight group and an overweight/obese group.
A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE (show APOE Antibodies) and with high risk of AD and cerebrovascular disease in the general population.
PGG enhances expression of SR-BI (show SCARB1 Antibodies) and ABCA1 in J774 and THP-1 (show GLI2 Antibodies) macrophages
These studies point to an important role for hematopoietic ABCA1 in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes.
These findings may be clinically relevant because HDL's APOE (show APOE Antibodies) content associates with CVD risk and ABCA1 deficiency promotes unregulated cholesterol accumulation in human macrophages.
Short-term modulation of miR (show MLXIP Antibodies)-27b expression in wild-type mice regulates hepatic LDLR (show LDLR Antibodies) and ABCA1 expression but does not influence plasma and hepatic lipid levels.
LXR (show NR1H3 Antibodies) activation reduces the growth of xenograft tumour of human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 expression and the decline of cholesterol levels in the tumour.
ABCA1(-/-) macrophages deposited much less extracellular cholesterol than wild-type macrophages. These findings demonstrate a novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix.
Our data suggest that GLP-1 (show GCG Antibodies)-based therapy modulate ABCA1/ABCG1 (show ABCG1 Antibodies) expression in adipocytes potentially through an LXR-alpha (show NR1H3 Antibodies) mediated process.
The authors identify the putative lipid transporter Abca1 as a critical mediator of LXR's anti-inflammatory effects.
SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response.
identifies ABCA1 as a key macromolecule facilitating bidirectional sterol movement at the PM and shows that ABCA1 controls retrograde sterol transport by modulating a certain clathrin-independent endocytic process
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Antibodies) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette 1