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anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Antibodies

The membrane-associated protein encoded by ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 Proteins (9) and ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCA4 24 P78363
ABCA4 11304 O35600
ABCA4 310836  
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Top anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Mouse Un-conjugated IHC (fro), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Mouse Rabbit Un-conjugated WB Anti-ABCA4 antibody, Western blotting All lanes: Anti ABCA4  at 0.5ug/... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB Anti-ABCA4 antibody, Western blotting WB: U87 Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Dog Rabbit Un-conjugated WB Western blot analysis of ABCA4 expression in HEK293T (A), NS-1 (B), PC... 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$375.83
Details
Cow Mouse Un-conjugated IHC, WB 100 μL Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Mouse Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Cow Mouse Un-conjugated IHC, WB 100 μL Log in to see 6 to 11 Days
$498.57
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details

ABCA4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 Antibodies

  1. Cow (Bovine) Monoclonal ABCA4 Primary Antibody for IHC (fro), WB - ABIN371821 : Illing, Molday, Molday: The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for ABIN371821

More Antibodies against ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 Interaction Partners

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 carriers demonstrated reduced macular function measured by mERG (show KCNH2 Antibodies) along with none to subtle and even extensive morphological retinal changes. The c.768 G>T, c.5461-10T>C, and c.319 C>T mutations were associated with the most deviant ERGs.

  2. 633C>A (CC+CA) genotype, 5646G>A and 6389T>A polymorphisms of ABCA4 gene and smoking are susceptible factors for age-related macular degeneration

  3. This family epitomizes the clinical and genetic complexity of ABCA4-associated diseases. It contained variants from all classes of mutations

  4. The mutation spectrum of the ABCA4 gene in Chinese patients is quite different from that for Caucasian patients. The establishment of the mutation profile will facilitate ABCA4 screening and risk evaluation for Chinese patients with STGD1.

  5. This study indicates that carriers of monoallelic ABCA4 mutations are phenotypically normal.

  6. With few exceptions, individuals heterozygous for ABCA4 mutations and between the ages of 9 and 60 years do not present with elevated qAF.

  7. The ABCA4 L541P;A1038V mutation causes severe retinal degenerations whereas the V mutation alone causes mild disease.

  8. Identification of Novel Mutations in ABCA4 Gene: Clinical and Genetic Analysis of Indian Patients with Stargardt Disease.

  9. Our findings demonstrate that minor alleles of common genetic variants in ABCA4 significantly reduce susceptibility to develop toxic maculopathy under chloroquine treatment.

  10. Stargardt eye disease ABCA4 R1108C and R1129C are both temperature-sensitive processing mutants that engage the cellular quality control mechanism and show a strong interaction with the chaperone Hsp 27 (show HSPB1 Antibodies).

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. Data indicate that knocking out the ATP-binding cassette transporter Abca4 gene correlated with an increase in all orange pigments.

  2. The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.

  3. Despite pronounced lipofuscin accumulation in the retinal pigment epithelium of Abca4(-/-) mice, ERG (show ERG Antibodies) and histology showed a slow age-related thinning of the photoreceptor layer similar to wild type controls up to 12 months.

  4. Abca4-deficient mice accumulate more of the toxic bisretinoid A2E than their ABCA4-competent counterparts which contribute to primary cone toxicity and may be associated with macular vision loss

  5. Mutations known to cause Stargardt disease decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activity of ABCA4

  6. The physiological role of Abca4 may include the translocation of 11-cis (show CISH Antibodies)-retinal complexes across the disk membrane

  7. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 (show ABCC6 Antibodies) in mice.

  8. Abcr (-/-) mice exhibit progressive photoreceptor cell loss that is detectable at 8 months of age and that has worsened by 11 and 13 months of age.

  9. In 2-month-old Abca4-/- mice, A2E was found in the center of the retinal pigment epithelial tissue; with age, A2E increased across the tissue

  10. A long wavelength fluorescence emission intrinsic to abca4(-/-) retinal explants is shown to emanate from A2PE-H(2).

Xenopus laevis ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. Evolutionary alterations may increase the retinoid metabolite recycling capacity of ABCA4 and may improve dark adaptation.

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 can transport N-11-cis (show CISH Antibodies)-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis (show CISH Antibodies)-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.

  2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction

  3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase (show DNAH8 Antibodies) activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function

  4. results indicate that ATP binding cassette protein (show ABCB5 Antibodies) ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity

ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Gene names and symbols associated with ABCA4

  • ATP-binding cassette, sub-family A (ABC1), member 4 (ABCA4) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 4 (abca4) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) antibody
  • ATP-binding cassette, subfamily A (ABC1), member 4 (Abca4) antibody
  • Abc10 antibody
  • Abcr antibody
  • ARMD2 antibody
  • AW050280 antibody
  • CORD3 antibody
  • D430003I15Rik antibody
  • FFM antibody
  • RmP antibody
  • RP19 antibody
  • STGD antibody
  • STGD1 antibody

Protein level used designations for ABCA4

ATP-binding cassette sub-family A member 4 , retinal-specific ATP transporter ABCA4 , ATP-binding cassette, sub-family A member 4 , ATP-binding cassette, sub-family A (ABC1), member 4 , retinal-specific ATP-binding cassette transporter-like , ATP binding cassette transporter , ATP-binding cassette transporter, retinal-specific , ATP-binding transporter, retina-specific , RIM ABC transporter , RIM protein , photoreceptor rim protein , retina-specific ABC transporter , retinal-specific ATP-binding cassette transporter , stargardt disease protein , ATP-binding cassette 10 , Rim protein , ATP-binding cassette, sub-family A, member 4 , retinal ABCA4 transporter

GENE ID SPECIES
424490 Gallus gallus
496442 Xenopus (Silurana) tropicalis
745972 Pan troglodytes
100393904 Callithrix jacchus
100440877 Pongo abelii
100479076 Ailuropoda melanoleuca
100605850 Nomascus leucogenys
24 Homo sapiens
444852 Canis lupus familiaris
11304 Mus musculus
497268 Xenopus laevis
281584 Bos taurus
310836 Rattus norvegicus
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