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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies (242) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1 5243 P08183
Rat ABCB1 ABCB1 170913  
Mouse ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
Yeast REACT_Entamoeba histolytica His tag   500 μg Log in to see 56 to 66 Days
$962.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details

ABCB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

Top referenced ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 (show ABCC1 Proteins) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in esophageal squamous cell carcinoma, and enhance tumor progression.

  2. ABCB1 polymorphisms were associated with the risk for osteonecrosis of the femoral head.

  3. IHC staining of human BCa (show BLNK Proteins) tissue supported our conclusion that the expression of HIF-1a (show HIF1A Proteins) and MDR1 was higher in chemoresistant tissue vs. chemosensitive tissue.

  4. The pharmacokinetics of silibinin was significantly influenced by ABCB1 C3435T polymorphism.

  5. The results of this study suggested that the treatment of major depressive disorder can be optimized by ABCB1 genotyping combined with monitoring of plasma drug concentrations.

  6. Findings indicated that fetuses of mothers with MDR1 TT genotype may be more susceptible to arsenic toxicity as compared to those of CC or CT genotypes.

  7. The ABCB1 variants modulate therapeutic response to modafinil and may partly explain pharmacoresistance in NT1 patients.

  8. The association of rs2032588 with antidepressant side effects suggests the involvement of the ABCB1 genotype in the clinical pharmacology of PGP-dependent antidepressants.

  9. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCA4 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  10. MDR1 gene rs1045642 C > T might confer an increase risk for ulcerative colitis.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  2. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  3. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  4. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

  5. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

  6. Expression of Abcb1 at the blood-brain and blood-spinal barriers is upregulated by Nrf2 (show NFE2L2 Proteins).

  7. The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs.

  8. Real-time polymerase chain reaction for ABC (show ABCB6 Proteins) transporters demonstrated that Abcb1a (show ABCB4 Proteins), Abcb1b (show ABCB4 Proteins) and Abcg2, regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit (show TBX19 Proteins)/F1 and LbetaT2 cells.

  9. In addition to ABCB1-mediated transport.

  10. In single Bcrp1 (show BANF1 Proteins)(-/-) mice, brain accumulation of CYT387 was more substantially increased than in Mdr1a (show ABCB4 Proteins)/1b(-/-) mice, suggesting that CYT387 is a slightly better substrate of Bcrp1 (show BANF1 Proteins) than of Mdr1a (show ABCB4 Proteins) at the blood-brain barrier.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (abcb1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • malic enzyme complex, mitochondrial (Mod2)
  • ABC20 protein
  • ABCB1 protein
  • Cd243 protein
  • CLCS protein
  • GP170 protein
  • Mdr protein
  • Mdr-1 protein
  • Mdr1 protein
  • Mdr1a protein
  • Mdr1b protein
  • Mod-2 protein
  • Mod-2r protein
  • Mod-2s protein
  • Mod2-r protein
  • Mod2-s protein
  • p-gp protein
  • PGP1 protein
  • Pgy-1 protein
  • Pgy1 protein
  • xemdr protein

Protein level used designations for ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPECIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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