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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (5) and many more products for this protein.
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Human Polyclonal ABCB1B Primary Antibody for IF (p), IHC (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
Show all 2 references for ABIN670161
Human Polyclonal ABCB1B Primary Antibody for IF (p), IHC (p) - ABIN686977
Mo, Pospichalova, Huang, Murphy, Payne, Wang, Kennedy, Cianciolo, Bryja, Pizzo, Bachelder: Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. in PLoS ONE 2015
The association of rs2032588 with antidepressant side effects suggests the involvement of the ABCB1 genotype in the clinical pharmacology of PGP-dependent antidepressants.
In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCA4 Antibodies) B1 by the HMG-CoA reductase (show HMGCR Antibodies) inhibitor simvastatin
MDR1 (show TBC1D9 Antibodies) gene rs1045642 C > T might confer an increase risk for ulcerative colitis.
Elevated expression of ABCB1 (show ABCB1 Antibodies) gene, through increase in mRNA stability is associated with Gastric Cancer.
There was significant difference in the genotype frequency of the ABCB1 (show ABCB1 Antibodies) gene compared to other populations.
The patients with GG genotypes had significantly higher incidence of this complaint[postoperative nausea and vomiting] (p=0.014). Polymorphism of ABCB1 (show ABCB1 Antibodies) has an association with responsiveness for ondansetron.
The combination of MTHFR (show MTHFR Antibodies), DRD3 (show DRD3 Antibodies) and MDR1 (show TBC1D9 Antibodies) polymorphisms associated with a slow ATV (show NBN Antibodies) metabolizer phenotype
results show that GSTT1 (show GSTT1 Antibodies) null and MDR1 (show TBC1D9 Antibodies) polymorphisms could play a role in susceptibility to inflammatory bowel disease
Shortening of the ABCB1 (show ABCB1 Antibodies) 3'-UTR (show UTS2R Antibodies) causes loss of miRNA-dependent translational control leading to elevated ABCB1 (show ABCB1 Antibodies) protein levels.
The TT genotype of the C3435T polymorphism of the ABCB1 (show ABCB1 Antibodies) gene and omeprazole usage were each associated with poor clopidogrel responsiveness .
In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Antibodies) B1 by the HMG-CoA reductase (show HMGCR Antibodies) inhibitor simvastatin
Efficient chemoprotection of CDD (show CDA Antibodies) and MDR1 (show ABCB4 Antibodies) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Antibodies)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (show ABCB1 Antibodies)-1Delta mutant mice following exposure to various P-gp (show ABCB4 Antibodies) substrates.
Data indicate that the brain penetration of ABT-888 in both Abcb1a (show ABCB4 Antibodies)/1b-/- and Abcb1a (show ABCB4 Antibodies)/1b-/-;Abcg2 (show ABCG2 Antibodies)-/- mice was significantly higher than in wild-type mice.
Expression of Abcb1 (show ABCB1 Antibodies) at the blood-brain and blood-spinal barriers is upregulated by Nrf2 (show NFE2L2 Antibodies).
The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs.
Real-time polymerase chain reaction for ABC (show ABCB6 Antibodies) transporters demonstrated that Abcb1a (show ABCB4 Antibodies), Abcb1b (show ABCB4 Antibodies) and Abcg2 (show ABCG2 Antibodies), regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit (show TBX19 Antibodies)/F1 and LbetaT2 cells.
In addition to ABCB1 (show ABCB1 Antibodies)-mediated transport.
In single Bcrp1 (show BANF1 Antibodies)(-/-) mice, brain accumulation of CYT387 was more substantially increased than in Mdr1a (show ABCB4 Antibodies)/1b(-/-) mice, suggesting that CYT387 is a slightly better substrate of Bcrp1 (show BANF1 Antibodies) than of Mdr1a (show ABCB4 Antibodies) at the blood-brain barrier.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1