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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
Rat ABCB1B ABCB1B 24646  
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast REACT_Entamoeba histolytica His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details

ABCB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. results suggest that some Japanese non-small-cell lung cancer patients treated with crizotinib developed clinically significant toxicities that were related to altered pharmacokinetics parameters due to ABCB1 (show ABCB1 Proteins) polymorphism and body weight factors

  2. The ABCB1 (show ABCB1 Proteins) gene polymorphism 3435C>T may be linked to individual differences in response to latanoprost eye drops treatment in primary open-angle glaucoma patients.

  3. The aims of this research were to investigate the association of TPMT (show TPMT Proteins) phenotypes with MDR1 genotypes.

  4. UCA1 functions as a competitive endogenous (ceRNA) of MDR1 through completely binding the common miR-16 (show GDE1 Proteins)

  5. Single nucleotide polymorphism C3435T (rs1045642) within MDR1 gene may be associated with an increased expression of P-gp (show ABCB4 Proteins) which affects the levels of antiepileptic drugs in plasma. The presented studies analysed the association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children.

  6. found that the MDR1 C3435T polymorphisms did not play an important role as a genetic risk factor for the development and progression of childhood ITP (show ITPA Proteins). However, patients carrying MDR1 (CC) genotypes had a higher risk to develop childhood ITP (show ITPA Proteins) at an older age and having lower initial platelet count than patients carrying other genotype

  7. We analyzed TNFalpha (show TNF Proteins), NOS 3 (show NANOS3 Proteins) and MDR1 in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP.

  8. ABCB1 (show ABCB1 Proteins) gene variants could affect the pharmacodynamics of rocuronium.

  9. C3435T polymorphism in the MDR1 gene appears not to be associated with sustained virological response in HCV-HIV co-infected individuals.

  10. The expression of ABCB1 (show ABCB1 Proteins), ABCC1 (show ABCC1 Proteins) and ABCG2 on primary human T-cells correlates with the efficacy of JAK (show JAK3 Proteins) inhibitor ruxolitinib treatment in regard to T-cell activation and proliferation.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  2. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  3. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  4. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  5. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (show ABCB1 Proteins)-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

  6. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

  7. Expression of Abcb1 (show ABCB1 Proteins) at the blood-brain and blood-spinal barriers is upregulated by Nrf2 (show NFE2L2 Proteins).

  8. The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs.

  9. Real-time polymerase chain reaction for ABC (show ABCB6 Proteins) transporters demonstrated that Abcb1a (show ABCB4 Proteins), Abcb1b (show ABCB4 Proteins) and Abcg2, regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit (show TBX19 Proteins)/F1 and LbetaT2 cells.

  10. In addition to ABCB1 (show ABCB1 Proteins)-mediated transport.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 protein
  • Abcb1 protein
  • CD243 protein
  • CLCS protein
  • GP170 protein
  • mdr protein
  • Mdr1 protein
  • Mdr1b protein
  • P-GP protein
  • Pgy-1 protein
  • Pgy1 protein

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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