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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
Rat ABCB1B ABCB1B 24646  
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast REACT_Entamoeba histolytica His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details

ABCB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in esophageal squamous cell carcinoma, and enhance tumor progression.

  2. ABCB1 (show ABCB1 Proteins) polymorphisms were associated with the risk for osteonecrosis of the femoral head.

  3. IHC staining of human BCa (show BLNK Proteins) tissue supported our conclusion that the expression of HIF-1a (show HIF1A Proteins) and MDR1 was higher in chemoresistant tissue vs. chemosensitive tissue.

  4. The pharmacokinetics of silibinin was significantly influenced by ABCB1 (show ABCB1 Proteins) C3435T polymorphism.

  5. The results of this study suggested that the treatment of major depressive disorder can be optimized by ABCB1 (show ABCB1 Proteins) genotyping combined with monitoring of plasma drug concentrations.

  6. Findings indicated that fetuses of mothers with MDR1 TT genotype may be more susceptible to arsenic toxicity as compared to those of CC or CT genotypes.

  7. The ABCB1 variants modulate therapeutic response to modafinil and may partly explain pharmacoresistance in NT1 patients.

  8. The association of rs2032588 with antidepressant side effects suggests the involvement of the ABCB1 genotype in the clinical pharmacology of PGP-dependent antidepressants.

  9. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCA4 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  10. MDR1 gene rs1045642 C > T might confer an increase risk for ulcerative colitis.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  2. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  3. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  4. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (show ABCB1 Proteins)-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

  5. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

  6. Expression of Abcb1 (show ABCB1 Proteins) at the blood-brain and blood-spinal barriers is upregulated by Nrf2 (show NFE2L2 Proteins).

  7. The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs.

  8. Real-time polymerase chain reaction for ABC (show ABCB6 Proteins) transporters demonstrated that Abcb1a (show ABCB4 Proteins), Abcb1b (show ABCB4 Proteins) and Abcg2, regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit (show TBX19 Proteins)/F1 and LbetaT2 cells.

  9. In addition to ABCB1 (show ABCB1 Proteins)-mediated transport.

  10. In single Bcrp1 (show BANF1 Proteins)(-/-) mice, brain accumulation of CYT387 was more substantially increased than in Mdr1a (show ABCB4 Proteins)/1b(-/-) mice, suggesting that CYT387 is a slightly better substrate of Bcrp1 (show BANF1 Proteins) than of Mdr1a (show ABCB4 Proteins) at the blood-brain barrier.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 protein
  • Abcb1 protein
  • CD243 protein
  • CLCS protein
  • GP170 protein
  • mdr protein
  • Mdr1 protein
  • Mdr1b protein
  • P-GP protein
  • Pgy-1 protein
  • Pgy1 protein

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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